Expression of ERK Signaling Inhibitors Dusp6, Dusp7, and Dusp9 During Mouse Ear Development

Overview

Journal Dev Dyn

Publisher Wiley

Specialty Anatomy & Histology

Date 2007 Dec 7

PMID 18058922

Citations 24

Authors

Lisa D Urness

Chaoying Li

Xiaofen Wang

Suzanne L Mansour

Affiliations

Soon will be listed here.

Abstract

The levels of fibroblast growth factor (FGF) signaling play important roles in coordinating development of the mouse inner, middle, and outer ears. Extracellular signal-regulated kinases (ERKs) are among the effectors that transduce the FGF signal to the nucleus and other cellular compartments. Attenuation of ERK activity by dephosphorylation is necessary to modulate the magnitude and duration of the FGF signal. Recently, we showed that inactivation of the ERK phosphatase, dual specificity phosphatase 6 (DUSP6), causes partially penetrant postnatal lethality, hearing loss and skeletal malformations. To determine whether other Dusps may function redundantly with Dusp6 during otic development, we surveyed the expression domains of the three ERK-specific DUSP transcripts, Dusp6, Dusp7, and Dusp9, in the embryonic mouse ear. We show that each is expressed in partially overlapping patterns that correspond to regions of active FGF signaling, suggesting combinatorial roles in negative regulation of this pathway during ear development.

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References

Lunn J, Fishwick K, Halley P, Storey K . A spatial and temporal map of FGF/Erk1/2 activity and response repertoires in the early chick embryo. Dev Biol. 2006; 302(2):536-52. DOI: 10.1016/j.ydbio.2006.10.014. View

Wright T, Hatch E, Karabagli H, Karabagli P, Schoenwolf G, Mansour S . Expression of mouse fibroblast growth factor and fibroblast growth factor receptor genes during early inner ear development. Dev Dyn. 2003; 228(2):267-72. DOI: 10.1002/dvdy.10362. View

Pirvola U, Zhang X, Mantela J, Ornitz D, Ylikoski J . Fgf9 signaling regulates inner ear morphogenesis through epithelial-mesenchymal interactions. Dev Biol. 2004; 273(2):350-60. DOI: 10.1016/j.ydbio.2004.06.010. View

Dickinson R, Keyse S . Diverse physiological functions for dual-specificity MAP kinase phosphatases. J Cell Sci. 2006; 119(Pt 22):4607-15. DOI: 10.1242/jcs.03266. View

Wright T, Mansour S . Fgf3 and Fgf10 are required for mouse otic placode induction. Development. 2003; 130(15):3379-90. DOI: 10.1242/dev.00555. View

Levy-Nissenbaum O, Sagi-Assif O, Kapon D, Hantisteanu S, Burg T, Raanani P . Dual-specificity phosphatase Pyst2-L is constitutively highly expressed in myeloid leukemia and other malignant cells. Oncogene. 2003; 22(48):7649-60. DOI: 10.1038/sj.onc.1206971. View

Hatch E, Noyes C, Wang X, Wright T, Mansour S . Fgf3 is required for dorsal patterning and morphogenesis of the inner ear epithelium. Development. 2007; 134(20):3615-25. PMC: 2366212. DOI: 10.1242/dev.006627. View

Hollway G, Suthers G, Battese K, Turner A, David D, Mulley J . Deafness due to Pro250Arg mutation of FGFR3. Lancet. 1998; 351(9106):877-8. DOI: 10.1016/S0140-6736(98)24012-8. View

Owens D, Keyse S . Differential regulation of MAP kinase signalling by dual-specificity protein phosphatases. Oncogene. 2007; 26(22):3203-13. DOI: 10.1038/sj.onc.1210412. View

10.

Hayashi T, Cunningham D, Bermingham-McDonogh O . Loss of Fgfr3 leads to excess hair cell development in the mouse organ of Corti. Dev Dyn. 2006; 236(2):525-33. DOI: 10.1002/dvdy.21026. View

11.

Partanen J, Schwartz L, Rossant J . Opposite phenotypes of hypomorphic and Y766 phosphorylation site mutations reveal a function for Fgfr1 in anteroposterior patterning of mouse embryos. Genes Dev. 1998; 12(15):2332-44. PMC: 317047. DOI: 10.1101/gad.12.15.2332. View

12.

Ruben R . Development of the inner ear of the mouse: a radioautographic study of terminal mitoses. Acta Otolaryngol. 1967; :Suppl 220:1-44. View

13.

Toydemir R, Brassington A, Bayrak-Toydemir P, Krakowiak P, Jorde L, Whitby F . A novel mutation in FGFR3 causes camptodactyly, tall stature, and hearing loss (CATSHL) syndrome. Am J Hum Genet. 2006; 79(5):935-41. PMC: 1698566. DOI: 10.1086/508433. View

14.

Rohmann E, Brunner H, Kayserili H, Uyguner O, Nurnberg G, Lew E . Mutations in different components of FGF signaling in LADD syndrome. Nat Genet. 2006; 38(4):414-7. DOI: 10.1038/ng1757. View

15.

Puligilla C, Feng F, Ishikawa K, Bertuzzi S, Dabdoub A, Griffith A . Disruption of fibroblast growth factor receptor 3 signaling results in defects in cellular differentiation, neuronal patterning, and hearing impairment. Dev Dyn. 2007; 236(7):1905-17. PMC: 3904742. DOI: 10.1002/dvdy.21192. View

16.

Abu-Issa R, Smyth G, Smoak I, Yamamura K, Meyers E . Fgf8 is required for pharyngeal arch and cardiovascular development in the mouse. Development. 2002; 129(19):4613-25. DOI: 10.1242/dev.129.19.4613. View

17.

Wright T, Mansour S . FGF signaling in ear development and innervation. Curr Top Dev Biol. 2003; 57:225-59. DOI: 10.1016/s0070-2153(03)57008-9. View

18.

Mason J, Morrison D, Basson M, Licht J . Sprouty proteins: multifaceted negative-feedback regulators of receptor tyrosine kinase signaling. Trends Cell Biol. 2005; 16(1):45-54. DOI: 10.1016/j.tcb.2005.11.004. View

19.

Ohuchi H, Yasue A, Ono K, Sasaoka S, Tomonari S, Takagi A . Identification of cis-element regulating expression of the mouse Fgf10 gene during inner ear development. Dev Dyn. 2005; 233(1):177-87. DOI: 10.1002/dvdy.20319. View

20.

Barald K, Kelley M . From placode to polarization: new tunes in inner ear development. Development. 2004; 131(17):4119-30. DOI: 10.1242/dev.01339. View