Preparation of Porous Apatite Granules from Calcium Phosphate Cement

Overview

Journal J Mater Sci Mater Med

Publisher Springer

Specialty Biomedical Engineering

Date 2007 Dec 1

PMID 18049869

Citations 12

Authors

A C Tas

Affiliations

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Abstract

A versatile method for preparing spherical, micro- and macroporous (micro: 2-10 and macro: 150-550 microm pores), carbonated apatitic calcium phosphate (Ap-CaP) granules (2-4 mm in size) was developed by using NaCl crystals as the porogen. The entire granule production was performed between 21 and 37 degrees C. A CaP cement powder, comprising alpha-Ca3(PO4)2 (61 wt.%), CaHPO4 (26%), CaCO3 (10%) and precipitated hydroxyapatite, Ca10(PO4)6(OH)2 (3%), was dry mixed with NaCl crystals varying in size from 420 microm to 1 mm. Cement powder (35 wt.%) and NaCl (65 wt.%) mixture was kneaded with an ethanol-Na2HPO4 initiator solution, and the formed dough was immediately agitated on an automatic sieve shaker for a few minutes to produce the spherical granules. Embedded NaCl crystals were then leached out of the granules by soaking them in deionized water. CaP granules were micro- and macroporous with a total porosity of 50% or more. Granules were composed of carbonated, poorly crystallized, apatitic CaP phase. These were the first spherical and porous CaP granules ever produced from a self-setting calcium phosphate cement. The granules reached their final handling strength at the ambient temperature through the cement setting reaction, without having a need for sintering.

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