Risk Assessment for Cancer Surgery in Elderly Patients

Overview

Journal Clin Interv Aging

Publisher Dove Medical Press

Specialty Geriatrics

Date 2007 Dec 1

PMID 18046874

Citations 17

Authors

Hodigere S J Ramesh

Tom Boase

Riccardo A Audisio

Affiliations

Soon will be listed here.

Abstract

Global growth of the elderly population is requiring healthcare providers to cater for an expanding elderly cancer subpopulation. The aggression with which cancer should be treated in this subpopulation is an ethical dilemma and is an ongoing debate, as surgeons have feared increases in postoperative morbidity and mortality. As a result elderly patients often receive suboptimal cancer treatment. The need for standardization of cancer surgery is well recognized despite the difficulties in view of heterogeneity of the group. In this article, epidemiological changes, tumor biology specific to elderly cancer are visited, operative risk assessment tools are discussed, and interim results of ongoing multinational investigation ie, PACE (Preoperative Assessment of Cancer Elderly) revealed.

Citing Articles

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References

Anisimov V . The relationship between aging and carcinogenesis: a critical appraisal. Crit Rev Oncol Hematol. 2003; 45(3):277-304. DOI: 10.1016/s1040-8428(02)00121-x. View

Ogle K, Swanson G, Woods N, Azzouz F . Cancer and comorbidity: redefining chronic diseases. Cancer. 2000; 88(3):653-63. DOI: 10.1002/(sici)1097-0142(20000201)88:3<653::aid-cncr24>3.0.co;2-1. View

Piantanelli L . Cancer and aging: from the kinetics of biological parameters to the kinetics of cancer incidence and mortality. Ann N Y Acad Sci. 1988; 521:99-109. DOI: 10.1111/j.1749-6632.1988.tb35268.x. View

Holmes C, Muss H . Diagnosis and treatment of breast cancer in the elderly. CA Cancer J Clin. 2003; 53(4):227-44. DOI: 10.3322/canjclin.53.4.227. View

Lawrence V, Dhanda R, Hilsenbeck S, Page C . Risk of pulmonary complications after elective abdominal surgery. Chest. 1996; 110(3):744-50. DOI: 10.1378/chest.110.3.744. View

Osiewacz H, Hamann A . DNA reorganization and biological aging. A review. Biochemistry (Mosc). 1998; 62(11):1275-84. View

Copeland G, Jones D, Walters M . POSSUM: a scoring system for surgical audit. Br J Surg. 1991; 78(3):355-60. DOI: 10.1002/bjs.1800780327. View

Audisio R, Osman N, Audisio M, Montalto F . How do we manage breast cancer in the elderly patients? A survey among members of the British Association of Surgical Oncologists (BASO). Crit Rev Oncol Hematol. 2004; 52(2):135-41. DOI: 10.1016/j.critrevonc.2004.08.002. View

Alexander H, Turnbull A, Salamone J, Keefe D, Melendez J . Upper abdominal cancer surgery in the very elderly. J Surg Oncol. 1991; 47(2):82-6. DOI: 10.1002/jso.2930470205. View

10.

Zhang X, Fujii H, Kishimoto H, Leroy E, Surh C, Sprent J . Aging leads to disturbed homeostasis of memory phenotype CD8(+) cells. J Exp Med. 2002; 195(3):283-93. PMC: 2193587. DOI: 10.1084/jem.20011267. View

11.

Firat S, Byhardt R, Gore E . Comorbidity and Karnofksy performance score are independent prognostic factors in stage III non-small-cell lung cancer: an institutional analysis of patients treated on four RTOG studies. Radiation Therapy Oncology Group. Int J Radiat Oncol Biol Phys. 2002; 54(2):357-64. DOI: 10.1016/s0360-3016(02)02939-5. View

12.

Chiappa A, Zbar A, Bertani E, Biella F, Audisio R, Staudacher C . Surgical outcomes for colorectal cancer patients including the elderly. Hepatogastroenterology. 2001; 48(38):440-4. View

13.

Cohen H . Biology of aging as related to cancer. Cancer. 1994; 74(7 Suppl):2092-100. DOI: 10.1002/1097-0142(19941001)74:7+<2092::aid-cncr2820741717>3.0.co;2-g. View

14.

Desch C, Hillner B, Smith T, Retchin S . Should the elderly receive chemotherapy for node-negative breast cancer? A cost-effectiveness analysis examining total and active life-expectancy outcomes. J Clin Oncol. 1993; 11(4):777-82. DOI: 10.1200/JCO.1993.11.4.777. View

15.

Wallach C, Kurtz R . Gastrointestinal cancer in the elderly. Gastroenterol Clin North Am. 1990; 19(2):419-32. View

16.

Vercelli M, Quaglia A, Casella C, Parodi S, Capocaccia R, Martinez Garcia C . Relative survival in elderly cancer patients in Europe. EUROCARE Working Group. Eur J Cancer. 1999; 34(14 Spec No):2264-70. DOI: 10.1016/s0959-8049(98)00325-6. View

17.

Audisio R, Gennari R, Sunouchi K, Nair H, Sestini A, Pope D . Preoperative assessment of cancer in elderly patients: a pilot study. Support Cancer Ther. 2008; 1(1):55-60. DOI: 10.3816/SCT.2003.n.005. View

18.

de Rijke J, Schouten L, Hillen H, Kiemeney L, Coebergh J, van den Brandt P . Cancer in the very elderly Dutch population. Cancer. 2000; 89(5):1121-33. DOI: 10.1002/1097-0142(20000901)89:5<1121::aid-cncr22>3.3.co;2-7. View

19.

Bann S, Sarin S . Comparative audit: the trouble with POSSUM. J R Soc Med. 2001; 94(12):632-4. PMC: 1282296. DOI: 10.1177/014107680109401207. View

20.

Silliman R, Balducci L, Goodwin J, Holmes F, Leventhal E . Breast cancer care in old age: what we know, don't know, and do. J Natl Cancer Inst. 1993; 85(3):190-9. DOI: 10.1093/jnci/85.3.190. View