Dectin-1 is Not Required for the Host Defense to Cryptococcus Neoformans

Overview

Journal Microbiol Immunol

Specialties Allergy & Immunology
Microbiology

Date 2007 Nov 27

PMID 18037789

Citations 52

Authors

Kiwamu Nakamura

Takeshi Kinjo

Shinobu Saijo

Akiko Miyazato

Yoshiyuki Adachi

Naohito Ohno

Jiro Fujita

Mitsuo Kaku

Yoichiro Iwakura

Kazuyoshi Kawakami

Affiliations

Soon will be listed here.

Abstract

Dectin-1 is known as a sole receptor for beta-glucan, a major cell wall component of fungal microorganisms. In the current study, we examined the role of this molecule in the host defense to Cryptococcus neoformans, an opportunistic fungal pathogen in AIDS patients. There was no significant difference in the clinical course and cytokine production between dectin-1 gene-deficient and control mice. These results indicate that dectin-1 is not likely essential for the development of host protective responses to C. neoformans.

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