Innate Immune Receptors and Defense Against Primary Pathogenic Fungi

Overview

Journal Vaccines (Basel)

Date 2020 Jun 18

PMID 32545735

Citations 10

Authors

Theo N Kirkland

Joshua Fierer

Affiliations

Soon will be listed here.

Abstract

The innate immune system is critical for natural resistance to all pathogenic microorganisms, including fungi. The innate response plays a vital role in resistance to infections before the antigen-specific immune response and also influences antigen-specific adaptive immunity. There are many different receptors for the innate immune response to fungi, and some receptors have been found to play a significant role in the response to human infections with opportunistic fungi. Most human infections are caused by opportunistic fungi, but a small number of organisms are capable of causing infections in normal hosts. The primary pathogenic fungi that cause invasive infections include spp., , spp., spp., and spp. In this review of innate immune receptors that play a role in infections caused by these organisms, we find that innate immunity differs between organisms.

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