Leishmanicidal and Trypanocidal Activities of 2-aminocyclohexanol and 1,2-cyclohexanediamine Derivatives

Overview

Journal Bioorg Med Chem Lett

Specialty Biochemistry

Date 2007 Nov 21

PMID 18024033

Citations 7

Authors

Oscar Rebollo

Esther Del Olmo

Grace Ruiz

Jose L Lopez-Perez

Alberto Gimenez

Arturo San Feliciano

Affiliations

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Abstract

A number of aminoalcohols, diamines and other related cycloanalogues of sphingosine have been synthesized and assayed in vitro against three Leishmania spp. and Trypanosoma cruzi. Most of the compounds were potent parasiticides, with IC50 values in the microM or lower range and potencies higher than those of pentamidine and benznidazol, the common therapeutic agents against these parasitoses.

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