Three-component Synthesis of Polysubstituted Homoproline Analogs

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2007 Nov 17

PMID 18007343

Citations 3

Authors

Konstantin V Kudryavtsev

Veronika V Irkha

Affiliations

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Abstract

Tetrasubstituted pyrrolidines representing analogs of homoproline were synthesized by three-component condensation of aryl(heteroaryl)aldehydes, asparagine and N-methylmaleimide (NMM). Compounds with (1S*, 3R*, 3aS*, 6aR*)-configuration at the corresponding carbon positions of the bicyclic pyrrolidine ring could be isolated ona preparative scale.

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(1SR,3RS,3aSR,6aRS)-Methyl 5-methyl-4,6-dioxo-3-[2-(trifluoro-meth-yl)phen-yl]octa-hydro-pyrrolo-[3,4-c]pyrrole-1-carboxyl-ate.

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References

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