» Articles » PMID: 17991757

N-3 Polyunsaturated Fatty Acid Supplementation Reverses Stress-induced Modifications on Brain Monoamine Levels in Mice

Overview
Journal J Lipid Res
Publisher Elsevier
Specialty Biochemistry
Date 2007 Nov 10
PMID 17991757
Citations 43
Authors
Affiliations
Soon will be listed here.
Abstract

The aim of this study was to examine the effects of supplementation with n-3 polyunsaturated fatty acids (PUFAs) on stress responses in mice subjected to an unpredictable chronic mild stress (UCMS) procedure. Stress-induced modifications in coat and aggressiveness were evaluated, and phospholipid PUFA profiles and monoamine levels were analyzed in the frontal cortex, hippocampus, and striatum. The results showed that repeated exposure to mild stressors induced degradation in the physical state of the coat, lowered body weight gain, and increased aggressiveness, without any effect of n-3 PUFA supplementation. The UCMS induced a significant decrease in the levels of norepinephrine in the frontal cortex and striatum, and a nonsignificant decrease in the hippocampus. The tissue levels of serotonin (5-HT) were 40% to 65% decreased in the three brain regions studied. Interestingly, the n-3 PUFA supplementation reversed this stress-induced reduction in 5-HT levels. These findings showed that supplementation in n-3 long-chain PUFAs might reverse certain effects of UCMS in cerebral structures involved in stress-related behaviors.

Citing Articles

Omega-3 PUFAs' efficacy in the therapy of coronary artery disease combined with anxiety or depression: a meta-analysis.

Gui Y, He D, Li J, Zhao H Front Psychiatry. 2024; 15:1368007.

PMID: 38979505 PMC: 11228296. DOI: 10.3389/fpsyt.2024.1368007.


Serotonin Signaling through Lipid Membranes.

Kalinichenko L, Kornhuber J, Sinning S, Haase J, Muller C ACS Chem Neurosci. 2024; 15(7):1298-1320.

PMID: 38499042 PMC: 10995955. DOI: 10.1021/acschemneuro.3c00823.


Lipids in major depressive disorder: new kids on the block or old friends revisited?.

van der Heijden A, Houben T Front Psychiatry. 2023; 14:1213011.

PMID: 37663599 PMC: 10469871. DOI: 10.3389/fpsyt.2023.1213011.


Therapeutic treatment with fluoxetine using the chronic unpredictable stress model induces changes in neurotransmitters and circulating miRNAs in extracellular vesicles.

Estevez-Cabrera M, Sanchez-Munoz F, Perez-Sanchez G, Pavon L, Hernandez-DiazCouder A, Cortes Altamirano J Heliyon. 2023; 9(2):e13442.

PMID: 36852042 PMC: 9958461. DOI: 10.1016/j.heliyon.2023.e13442.


Natural Bioactive Molecules as Neuromedicines for the Treatment/Prevention of Neurodegenerative Diseases.

Babazadeh A, Vahed F, Liu Q, Siddiqui S, Kharazmi M, Jafari S ACS Omega. 2023; 8(4):3667-3683.

PMID: 36743024 PMC: 9893457. DOI: 10.1021/acsomega.2c06098.