Maternal Pre-pregnancy Obesity and Diagnosis of Asthma in Offspring at Age 3 Years

Overview

Journal Matern Child Health J

Specialty Health Services

Date 2007 Nov 8

PMID 17987372

Citations 31

Authors

Nancy E Reichman

Lenna Nepomnyaschy

Affiliations

Soon will be listed here.

Abstract

Objective: The objective of this study was to examine the relationship between maternal pre-pregnancy obesity and a diagnosis of asthma in offspring at age 3 years.

Methods: A population-based sample of children born in large U.S. cities in 1998-2000 was followed since birth (N=1971). The main outcome measure was whether the mother reported at 3 years that the child had ever been diagnosed with asthma. Multilevel logistic regression models were used to estimate the association between maternal pre-pregnancy obesity and child asthma diagnosis, as well as the extent to which the association can be explained by sociodemographic, medical, obstetric, and behavioral factors associated with both conditions.

Results: Children with obese mothers had 52% higher odds of having an asthma diagnosis by age 3 (OR=1.52; 95% CI: 1.18-1.93). Sociodemographic, medical, obstetric, and behavioral factors explained some, but not all, of the association.

Conclusions: Maternal pre-pregnancy obesity is associated with diagnosis of asthma in offspring at age 3 years. The results from this study are preliminary and need to be replicated and further explored, but are suggestive of a complex intergenerational linkage between obesity and asthma.

Citing Articles

Life Course of Asthma.

Farooq S, Khatri S Adv Exp Med Biol. 2023; 1426:43-76.

PMID: 37464116 DOI: 10.1007/978-3-031-32259-4_3.

Maternal Bariatric Surgery and Offspring Health: A Sibling Matched Analysis Comparing Offspring Born before and after the Surgery.

Gothelf I, Sheiner E, Wainstock T J Clin Med. 2023; 12(9).

PMID: 37176496 PMC: 10179329. DOI: 10.3390/jcm12093056.

Relation of Maternal Pre-Pregnancy Factors and Childhood Asthma: A Cross-Sectional Survey in Pre-School Children Aged 2-5 Years Old.

Papandreou D, Pavlidou E, Tyrovolas S, Mantzorou M, Andreou E, Psara E Medicina (Kaunas). 2023; 59(1).

PMID: 36676802 PMC: 9867101. DOI: 10.3390/medicina59010179.

Maternal pre-pregnancy body mass index and mental health problems in early adolescents from the 2004 Pelotas birth cohort.

Quinte G, Munhoz T, Matijasevich A, Santos I Sci Rep. 2022; 12(1):14437.

PMID: 36002596 PMC: 9402554. DOI: 10.1038/s41598-022-18032-y.

Examining the role of pre-pregnancy weight and gestational weight gain in allergic disease development among offspring: A population-based cohort study in Ontario, Canada.

Srugo S, Fell D, Corsi D, Fakhraei R, Guo Y, Gaudet L Paediatr Perinat Epidemiol. 2021; 36(1):144-155.

PMID: 34396579 PMC: 9275258. DOI: 10.1111/ppe.12806.

References

Watkins M, Rasmussen S, Honein M, Botto L, Moore C . Maternal obesity and risk for birth defects. Pediatrics. 2003; 111(5 Pt 2):1152-8. View

Akinbami L, Rhodes J, Lara M . Racial and ethnic differences in asthma diagnosis among children who wheeze. Pediatrics. 2005; 115(5):1254-60. DOI: 10.1542/peds.2004-0897. View

King J . Maternal obesity, metabolism, and pregnancy outcomes. Annu Rev Nutr. 2006; 26:271-91. DOI: 10.1146/annurev.nutr.24.012003.132249. View

Ford E . The epidemiology of obesity and asthma. J Allergy Clin Immunol. 2005; 115(5):897-909. DOI: 10.1016/j.jaci.2004.11.050. View

Barker D . Fetal origins of coronary heart disease. BMJ. 1995; 311(6998):171-4. PMC: 2550226. DOI: 10.1136/bmj.311.6998.171. View

Catalano P, Ehrenberg H . The short- and long-term implications of maternal obesity on the mother and her offspring. BJOG. 2006; 113(10):1126-33. DOI: 10.1111/j.1471-0528.2006.00989.x. View

Guler N, Kirerleri E, Ones U, Tamay Z, Salmayenli N, Darendeliler F . Leptin: does it have any role in childhood asthma?. J Allergy Clin Immunol. 2004; 114(2):254-9. DOI: 10.1016/j.jaci.2004.03.053. View

Nafstad P, Samuelsen S, Irgens L, Bjerkedal T . Pregnancy complications and the risk of asthma among Norwegians born between 1967 and 1993. Eur J Epidemiol. 2003; 18(8):755-61. DOI: 10.1023/a:1025395405101. View

Boney C, Verma A, Tucker R, Vohr B . Metabolic syndrome in childhood: association with birth weight, maternal obesity, and gestational diabetes mellitus. Pediatrics. 2005; 115(3):e290-6. DOI: 10.1542/peds.2004-1808. View

10.

Robinson H, OConnell C, Joseph K, McLeod N . Maternal outcomes in pregnancies complicated by obesity. Obstet Gynecol. 2005; 106(6):1357-64. DOI: 10.1097/01.AOG.0000188387.88032.41. View

11.

G Healton C, Vallone D, McCausland K, Xiao H, Green M . Smoking, obesity, and their co-occurrence in the United States: cross sectional analysis. BMJ. 2006; 333(7557):25-6. PMC: 1488756. DOI: 10.1136/bmj.38840.608704.80. View

12.

Lucas A . Role of nutritional programming in determining adult morbidity. Arch Dis Child. 1994; 71(4):288-90. PMC: 1030003. DOI: 10.1136/adc.71.4.288. View

13.

Baeten J, Bukusi E, Lambe M . Pregnancy complications and outcomes among overweight and obese nulliparous women. Am J Public Health. 2001; 91(3):436-40. PMC: 1446581. DOI: 10.2105/ajph.91.3.436. View

14.

Hartert T, Peebles Jr R . Epidemiology of asthma: the year in review. Curr Opin Pulm Med. 1999; 6(1):4-9. DOI: 10.1097/00063198-200001000-00002. View

15.

Maier W, Arrighi H, Morray B, Llewllyn C, Redding G . The impact of asthma and asthma-like illness in Seattle school children. J Clin Epidemiol. 1998; 51(7):557-68. DOI: 10.1016/s0895-4356(98)00027-4. View

16.

Weiss J, Malone F, Emig D, Ball R, Nyberg D, Comstock C . Obesity, obstetric complications and cesarean delivery rate--a population-based screening study. Am J Obstet Gynecol. 2004; 190(4):1091-7. DOI: 10.1016/j.ajog.2003.09.058. View

17.

Armitage J, Taylor P, Poston L . Experimental models of developmental programming: consequences of exposure to an energy rich diet during development. J Physiol. 2005; 565(Pt 1):3-8. PMC: 1464498. DOI: 10.1113/jphysiol.2004.079756. View

18.

Xu B, Pekkanen J, Jarvelin M, Olsen P, Hartikainen A . Maternal infections in pregnancy and the development of asthma among offspring. Int J Epidemiol. 1999; 28(4):723-7. DOI: 10.1093/ije/28.4.723. View

19.

Morland K, Diez Roux A, Wing S . Supermarkets, other food stores, and obesity: the atherosclerosis risk in communities study. Am J Prev Med. 2006; 30(4):333-9. DOI: 10.1016/j.amepre.2005.11.003. View

20.

Joseph C, Foxman B, Leickly F, Peterson E, Ownby D . Prevalence of possible undiagnosed asthma and associated morbidity among urban schoolchildren. J Pediatr. 1996; 129(5):735-42. DOI: 10.1016/s0022-3476(96)70158-0. View