A Study on Mediation by Offspring BMI in the Association Between Maternal Obesity and Child Respiratory Outcomes in the Amsterdam Born and Their Development Study Cohort

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2015 Oct 21

PMID 26485533

Citations 16

Authors

Margreet W Harskamp-van Ginkel

Stephanie J London

Maria C Magnus

Maaike G Gademan

Tanja G Vrijkotte

Affiliations

Soon will be listed here.

Abstract

Background: A causal relationship between maternal obesity and offspring asthma is hypothesized to begin during early development, but no underlying mechanism for the found association is identified. We quantitatively examined mediation by offspring body mass index (BMI) in the association of maternal pre-pregnancy BMI on risk of asthma and wheezing during the first 7-8 years of life in a large Amsterdam born birth cohort.

Methods: For 3185 mother-child pairs, mothers reported maternal pre-pregnancy BMI and offspring outcomes "ever being diagnosed with asthma" and "wheezing in the past 12 months" on questionnaires. We measured offspring height and weight at age 5-6 years. We performed a multivariate log linear regression comparing outcomes in offspring of mothers with different BMI categories. For each category we quantified and tested mediation by offspring BMI and also investigated interaction by parental asthma.

Results: At the age of 7-8 years, 8% of the offspring ever had asthma and 7% had current wheezing. Maternal pre-pregnancy obesity was associated with higher risks of asthma (adjusted RR 2.32 (95% CI: 1.49-3.61) and wheezing (adjusted RR 2.16 (95% CI: 1.28-3.64). Offspring BMI was a mediator in the association between maternal BMI and offspring wheezing, but not for asthma. There was no interaction by parental asthma.

Conclusions: Maternal pre-pregnancy obesity was associated with higher risks of offspring asthma and wheezing. The association between maternal obesity and offspring wheezing was both direct and indirect (mediated) through the child's own BMI.

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References

Tromp M, van Eijsden M, Ravelli A, Bonsel G . Anonymous non-response analysis in the ABCD cohort study enabled by probabilistic record linkage. Paediatr Perinat Epidemiol. 2009; 23(3):264-72. DOI: 10.1111/j.1365-3016.2009.01030.x. View

van Eijsden M, Vrijkotte T, Gemke R, van der Wal M . Cohort profile: the Amsterdam Born Children and their Development (ABCD) study. Int J Epidemiol. 2010; 40(5):1176-86. DOI: 10.1093/ije/dyq128. View

Pike K, Inskip H, Robinson S, Cooper C, Godfrey K, Roberts G . The relationship between maternal adiposity and infant weight gain, and childhood wheeze and atopy. Thorax. 2013; 68(4):372-9. PMC: 3661999. DOI: 10.1136/thoraxjnl-2012-202556. View

Harpsoe M, Basit S, Bager P, Wohlfahrt J, Benn C, Nohr E . Maternal obesity, gestational weight gain, and risk of asthma and atopic disease in offspring: a study within the Danish National Birth Cohort. J Allergy Clin Immunol. 2012; 131(4):1033-40. DOI: 10.1016/j.jaci.2012.09.008. View

Forno E, Young O, Kumar R, Simhan H, Celedon J . Maternal obesity in pregnancy, gestational weight gain, and risk of childhood asthma. Pediatrics. 2014; 134(2):e535-46. PMC: 4187236. DOI: 10.1542/peds.2014-0439. View

Barker D, Martyn C . The maternal and fetal origins of cardiovascular disease. J Epidemiol Community Health. 1992; 46(1):8-11. PMC: 1059485. DOI: 10.1136/jech.46.1.8. View

Akinbami L, Moorman J, Bailey C, Zahran H, King M, Johnson C . Trends in asthma prevalence, health care use, and mortality in the United States, 2001-2010. NCHS Data Brief. 2012; (94):1-8. View

Textor J, Hardt J, Knuppel S . DAGitty: a graphical tool for analyzing causal diagrams. Epidemiology. 2011; 22(5):745. DOI: 10.1097/EDE.0b013e318225c2be. View

Catalano P . Obesity, insulin resistance, and pregnancy outcome. Reproduction. 2010; 140(3):365-71. PMC: 4179873. DOI: 10.1530/REP-10-0088. View

10.

Papoutsakis C, Priftis K, Drakouli M, Prifti S, Konstantaki E, Chondronikola M . Childhood overweight/obesity and asthma: is there a link? A systematic review of recent epidemiologic evidence. J Acad Nutr Diet. 2012; 113(1):77-105. DOI: 10.1016/j.jand.2012.08.025. View

11.

Moller L, de Hoog M, van Eijsden M, Gemke R, Vrijkotte T . Infant nutrition in relation to eating behaviour and fruit and vegetable intake at age 5 years. Br J Nutr. 2012; 109(3):564-71. DOI: 10.1017/S0007114512001237. View

12.

De Vries A, Reynolds R, Seckl J, van der Wal M, Bonsel G, Vrijkotte T . Increased maternal BMI is associated with infant wheezing in early life: a prospective cohort study. J Dev Orig Health Dis. 2014; 5(5):351-60. DOI: 10.1017/S2040174414000312. View

13.

Kumar R, Story R, Pongracic J, Hong X, Arguelles L, Wang G . Maternal Pre-Pregnancy Obesity and Recurrent Wheezing in Early Childhood. Pediatr Allergy Immunol Pulmonol. 2012; 23(3):183-190. PMC: 3281288. DOI: 10.1089/ped.2010.0032. View

14.

Patel S, Rodriguez A, Little M, Elliott P, Pekkanen J, Hartikainen A . Associations between pre-pregnancy obesity and asthma symptoms in adolescents. J Epidemiol Community Health. 2011; 66(9):809-14. PMC: 3412048. DOI: 10.1136/jech.2011.133777. View

15.

Dekkers J, van Wier M, Hendriksen I, Twisk J, van Mechelen W . Accuracy of self-reported body weight, height and waist circumference in a Dutch overweight working population. BMC Med Res Methodol. 2008; 8:69. PMC: 2605752. DOI: 10.1186/1471-2288-8-69. View

16.

Wright R, Fisher K, Chiu Y, Wright R, Fein R, Cohen S . Disrupted prenatal maternal cortisol, maternal obesity, and childhood wheeze. Insights into prenatal programming. Am J Respir Crit Care Med. 2013; 187(11):1186-93. PMC: 4412399. DOI: 10.1164/rccm.201208-1530OC. View

17.

Scholtens S, Wijga A, Brunekreef B, Kerkhof M, Postma D, Oldenwening M . Maternal overweight before pregnancy and asthma in offspring followed for 8 years. Int J Obes (Lond). 2009; 34(4):606-13. DOI: 10.1038/ijo.2009.194. View

18.

White I, Royston P, Wood A . Multiple imputation using chained equations: Issues and guidance for practice. Stat Med. 2011; 30(4):377-99. DOI: 10.1002/sim.4067. View

19.

Finucane M, Stevens G, Cowan M, Danaei G, Lin J, Paciorek C . National, regional, and global trends in body-mass index since 1980: systematic analysis of health examination surveys and epidemiological studies with 960 country-years and 9·1 million participants. Lancet. 2011; 377(9765):557-67. PMC: 4472365. DOI: 10.1016/S0140-6736(10)62037-5. View

20.

Willeboordse M, van den Bersselaar D, van de Kant K, Muris J, van Schayck O, Dompeling E . Sex differences in the relationship between asthma and overweight in Dutch children: a survey study. PLoS One. 2013; 8(10):e77574. PMC: 3804131. DOI: 10.1371/journal.pone.0077574. View