Regulation of IL-17 Production in Human Lymphocytes

Overview

Journal Cytokine

Specialties Allergy & Immunology
Biology

Date 2007 Nov 6

PMID 17981475

Citations 45

Authors

Zhi Chen

John J OShea

Affiliations

Soon will be listed here.

Abstract

The discovery of a new lineage of helper T cells that selectively produces interleukin (IL)-17 has provided exciting new insights into immunoregulation, host defense and the pathogenesis of autoimmune diseases. Although the factors that promote murine Th17 differentiation have been intensively examined, there has been much less information on the regulation of this cytokine in human T cells. IL-17 is readily produced by human memory T cells, which we now know exhibit distinct patterns of chemokine receptor expression and may differentiate in response to selective pathogens. Recently it has been shown that IL-1, IL-6 and IL-23 are important in driving human Th17 differentiation. However, TGFbeta-1 which is important for the differentiation of murine Th17 cells and inducible regulatory T cells (iTregs), is reportedly not required and even inhibits for human Th17 differentiation. In addition, human Th17 cells also produce other proinflammatory cytokines. Further characterization of the transcription regulation of human IL-17 expression, and the epigenetic regulation of human Il17 locus should improve our understanding the lineage commitment of human Th17 cells. Targeting the production and action of this cytokine is also likely to be beneficial therapeutically for autoinflammatory and autoimmune diseases.

Citing Articles

Pathophysiology of ocular toxoplasmosis: Facts and open questions.

Greigert V, Bittich-Fahmi F, Pfaff A PLoS Negl Trop Dis. 2020; 14(12):e0008905.

PMID: 33382688 PMC: 7774838. DOI: 10.1371/journal.pntd.0008905.

The Role of Mesenchymal Stem Cells in Radiation-Induced Lung Fibrosis.

Zanoni M, Cortesi M, Zamagni A, Tesei A Int J Mol Sci. 2019; 20(16).

PMID: 31398940 PMC: 6719901. DOI: 10.3390/ijms20163876.

Role of T-cell activation in salt-sensitive hypertension.

Ren J, Crowley S Am J Physiol Heart Circ Physiol. 2019; 316(6):H1345-H1353.

PMID: 30901277 PMC: 6620682. DOI: 10.1152/ajpheart.00096.2019.

IL-26, a Cytokine With Roles in Extracellular DNA-Induced Inflammation and Microbial Defense.

Larochette V, Miot C, Poli C, Beaumont E, Roingeard P, Fickenscher H Front Immunol. 2019; 10:204.

PMID: 30809226 PMC: 6379347. DOI: 10.3389/fimmu.2019.00204.

Quantitative proteomic characterization and comparison of T helper 17 and induced regulatory T cells.

Mohammad I, Nousiainen K, Bhosale S, Starskaia I, Moulder R, Rokka A PLoS Biol. 2018; 16(5):e2004194.

PMID: 29851958 PMC: 5979006. DOI: 10.1371/journal.pbio.2004194.

References

Shevach E . From vanilla to 28 flavors: multiple varieties of T regulatory cells. Immunity. 2006; 25(2):195-201. DOI: 10.1016/j.immuni.2006.08.003. View

Schambach F, Schupp M, Lazar M, Reiner S . Activation of retinoic acid receptor-alpha favours regulatory T cell induction at the expense of IL-17-secreting T helper cell differentiation. Eur J Immunol. 2007; 37(9):2396-9. DOI: 10.1002/eji.200737621. View

Lee G, Kim S, Spilianakis C, Fields P, Flavell R . T helper cell differentiation: regulation by cis elements and epigenetics. Immunity. 2006; 24(4):369-79. DOI: 10.1016/j.immuni.2006.03.007. View

Rengarajan J, Mowen K, McBride K, Smith E, Singh H, Glimcher L . Interferon regulatory factor 4 (IRF4) interacts with NFATc2 to modulate interleukin 4 gene expression. J Exp Med. 2002; 195(8):1003-12. PMC: 2193700. DOI: 10.1084/jem.20011128. View

Teunissen M, Koomen C, de Waal Malefyt R, Wierenga E, Bos J . Interleukin-17 and interferon-gamma synergize in the enhancement of proinflammatory cytokine production by human keratinocytes. J Invest Dermatol. 1998; 111(4):645-9. DOI: 10.1046/j.1523-1747.1998.00347.x. View

Hu C, Jang S, Fanzo J, Pernis A . Modulation of T cell cytokine production by interferon regulatory factor-4. J Biol Chem. 2002; 277(51):49238-46. DOI: 10.1074/jbc.M205895200. View

Albanesi C, Scarponi C, Cavani A, Federici M, Nasorri F, Girolomoni G . Interleukin-17 is produced by both Th1 and Th2 lymphocytes, and modulates interferon-gamma- and interleukin-4-induced activation of human keratinocytes. J Invest Dermatol. 2000; 115(1):81-7. DOI: 10.1046/j.1523-1747.2000.00041.x. View

Acosta-Rodriguez E, Rivino L, Geginat J, Jarrossay D, Gattorno M, Lanzavecchia A . Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells. Nat Immunol. 2007; 8(6):639-46. DOI: 10.1038/ni1467. View

Bettelli E, Carrier Y, Gao W, Korn T, Strom T, Oukka M . Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature. 2006; 441(7090):235-8. DOI: 10.1038/nature04753. View

10.

Veldhoen M, Hocking R, Atkins C, Locksley R, Stockinger B . TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity. 2006; 24(2):179-89. DOI: 10.1016/j.immuni.2006.01.001. View

11.

Wong P, Egan P, Croker B, ODonnell K, Sims N, Drake S . SOCS-3 negatively regulates innate and adaptive immune mechanisms in acute IL-1-dependent inflammatory arthritis. J Clin Invest. 2006; 116(6):1571-81. PMC: 1462939. DOI: 10.1172/JCI25660. View

12.

Amadi-Obi A, Yu C, Liu X, Mahdi R, Clarke G, Nussenblatt R . TH17 cells contribute to uveitis and scleritis and are expanded by IL-2 and inhibited by IL-27/STAT1. Nat Med. 2007; 13(6):711-8. DOI: 10.1038/nm1585. View

13.

Kullberg M, Jankovic D, Feng C, Hue S, Gorelick P, McKenzie B . IL-23 plays a key role in Helicobacter hepaticus-induced T cell-dependent colitis. J Exp Med. 2006; 203(11):2485-94. PMC: 2118119. DOI: 10.1084/jem.20061082. View

14.

Kryczek I, Wei S, Zou L, Altuwaijri S, Szeliga W, Kolls J . Cutting edge: Th17 and regulatory T cell dynamics and the regulation by IL-2 in the tumor microenvironment. J Immunol. 2007; 178(11):6730-3. DOI: 10.4049/jimmunol.178.11.6730. View

15.

Vaknin-Dembinsky A, Balashov K, Weiner H . IL-23 is increased in dendritic cells in multiple sclerosis and down-regulation of IL-23 by antisense oligos increases dendritic cell IL-10 production. J Immunol. 2006; 176(12):7768-74. DOI: 10.4049/jimmunol.176.12.7768. View

16.

Yen D, Cheung J, Scheerens H, Poulet F, Mcclanahan T, McKenzie B . IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6. J Clin Invest. 2006; 116(5):1310-6. PMC: 1451201. DOI: 10.1172/JCI21404. View

17.

Lock C, Hermans G, Pedotti R, Brendolan A, Schadt E, Garren H . Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis. Nat Med. 2002; 8(5):500-8. DOI: 10.1038/nm0502-500. View

18.

Park H, Li Z, Yang X, Chang S, Nurieva R, Wang Y . A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat Immunol. 2005; 6(11):1133-41. PMC: 1618871. DOI: 10.1038/ni1261. View

19.

Wilson N, Boniface K, Chan J, McKenzie B, Blumenschein W, Mattson J . Development, cytokine profile and function of human interleukin 17-producing helper T cells. Nat Immunol. 2007; 8(9):950-7. DOI: 10.1038/ni1497. View

20.

Yang X, Panopoulos A, Nurieva R, Chang S, Wang D, Watowich S . STAT3 regulates cytokine-mediated generation of inflammatory helper T cells. J Biol Chem. 2007; 282(13):9358-9363. DOI: 10.1074/jbc.C600321200. View