Understanding the Benign Nature of SIV Infection in Natural Hosts

Overview

Journal J Clin Invest

Specialty General Medicine

Date 2007 Nov 3

PMID 17975656

Citations 123

Authors

Guido Silvestri

Mirko Paiardini

Ivona Pandrea

Michael M Lederman

Donald L Sodora

Affiliations

Soon will be listed here.

Abstract

In striking contrast to HIV infection, natural SIV infection of African nonhuman primates is asymptomatic and usually does not induce significant CD4+ T cell depletion despite high levels of virus replication. Recently, significant progress has been made in understanding the mechanisms underlying the remarkable difference in infection outcome between natural and nonnatural HIV/SIV hosts. These advances include the identification of limited immune activation as a key factor protecting natural SIV hosts from AIDS and the discovery of low CC chemokine receptor 5 expression on CD4+ T cells as a specific and consistent immunologic feature in these animals. Further elucidation of the pathways by which the differences in immune activation between natural and nonnatural hosts are manifest holds promise for the design of novel therapeutic approaches to HIV infection.

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References

Zhou D, Lai X, Shen Y, Sehgal P, Shen L, Simon M . Inhibition of adaptive Vgamma2Vdelta2+ T-cell responses during active mycobacterial coinfection of simian immunodeficiency virus SIVmac-infected monkeys. J Virol. 2003; 77(5):2998-3006. PMC: 149773. DOI: 10.1128/jvi.77.5.2998-3006.2003. View

Gautam R, Carter A, Katz N, Butler I, Barnes M, Hasegawa A . In vitro characterization of primary SIVsmm isolates belonging to different lineages. In vitro growth on rhesus macaque cells is not predictive for in vivo replication in rhesus macaques. Virology. 2007; 362(2):257-70. PMC: 1936220. DOI: 10.1016/j.virol.2006.12.037. View

Hazenberg M, Hamann D, Schuitemaker H, Miedema F . T cell depletion in HIV-1 infection: how CD4+ T cells go out of stock. Nat Immunol. 2001; 1(4):285-9. DOI: 10.1038/79724. View

Estes J, Wietgrefe S, Schacker T, Southern P, Beilman G, Reilly C . Simian immunodeficiency virus-induced lymphatic tissue fibrosis is mediated by transforming growth factor beta 1-positive regulatory T cells and begins in early infection. J Infect Dis. 2007; 195(4):551-61. DOI: 10.1086/510852. View

Onanga R, Souquiere S, Makuwa M, Mouinga-Ondeme A, Simon F, Apetrei C . Primary simian immunodeficiency virus SIVmnd-2 infection in mandrills (Mandrillus sphinx). J Virol. 2006; 80(7):3301-9. PMC: 1440382. DOI: 10.1128/JVI.80.7.3301-3309.2006. View

Goldstein S, Ourmanov I, Brown C, Beer B, Elkins W, Plishka R . Wide range of viral load in healthy african green monkeys naturally infected with simian immunodeficiency virus. J Virol. 2000; 74(24):11744-53. PMC: 112457. DOI: 10.1128/jvi.74.24.11744-11753.2000. View

Brenchley J, Price D, Schacker T, Asher T, Silvestri G, Rao S . Microbial translocation is a cause of systemic immune activation in chronic HIV infection. Nat Med. 2006; 12(12):1365-71. DOI: 10.1038/nm1511. View

Staprans S, Dailey P, Rosenthal A, Horton C, Grant R, Lerche N . Simian immunodeficiency virus disease course is predicted by the extent of virus replication during primary infection. J Virol. 1999; 73(6):4829-39. PMC: 112526. DOI: 10.1128/JVI.73.6.4829-4839.1999. View

Hirsch V . What can natural infection of African monkeys with simian immunodeficiency virus tell us about the pathogenesis of AIDS?. AIDS Rev. 2004; 6(1):40-53. View

10.

Picker L, Hagen S, Lum R, Reed-Inderbitzin E, Daly L, Sylwester A . Insufficient production and tissue delivery of CD4+ memory T cells in rapidly progressive simian immunodeficiency virus infection. J Exp Med. 2004; 200(10):1299-314. PMC: 2211921. DOI: 10.1084/jem.20041049. View

11.

Sumpter B, Dunham R, Gordon S, Engram J, Hennessy M, Kinter A . Correlates of preserved CD4(+) T cell homeostasis during natural, nonpathogenic simian immunodeficiency virus infection of sooty mangabeys: implications for AIDS pathogenesis. J Immunol. 2007; 178(3):1680-91. DOI: 10.4049/jimmunol.178.3.1680. View

12.

Grossman Z, Meier-Schellersheim M, Sousa A, Victorino R, Paul W . CD4+ T-cell depletion in HIV infection: are we closer to understanding the cause?. Nat Med. 2002; 8(4):319-23. DOI: 10.1038/nm0402-319. View

13.

Apetrei C, Gautam R, Sumpter B, Carter A, Gaufin T, Staprans S . Virus subtype-specific features of natural simian immunodeficiency virus SIVsmm infection in sooty mangabeys. J Virol. 2007; 81(15):7913-23. PMC: 1951324. DOI: 10.1128/JVI.00281-07. View

14.

Pandrea I, Apetrei C, Dufour J, Dillon N, Barbercheck J, Metzger M . Simian immunodeficiency virus SIVagm.sab infection of Caribbean African green monkeys: a new model for the study of SIV pathogenesis in natural hosts. J Virol. 2006; 80(10):4858-67. PMC: 1472068. DOI: 10.1128/JVI.80.10.4858-4867.2006. View

15.

Martinez-Maza O, Crabb E, Mitsuyasu R, Fahey J, Giorgi J . Infection with the human immunodeficiency virus (HIV) is associated with an in vivo increase in B lymphocyte activation and immaturity. J Immunol. 1987; 138(11):3720-4. View

16.

Dunham R, Pagliardini P, Gordon S, Sumpter B, Engram J, Moanna A . The AIDS resistance of naturally SIV-infected sooty mangabeys is independent of cellular immunity to the virus. Blood. 2006; 108(1):209-17. PMC: 1895834. DOI: 10.1182/blood-2005-12-4897. View

17.

Berthier J, Chaduc Y, Montagnier L, Hovanessian A, Chakrabarti L . Simian immunodeficiency virus replicates to high levels in sooty mangabeys without inducing disease. J Virol. 1998; 72(5):3872-86. PMC: 109612. DOI: 10.1128/JVI.72.5.3872-3886.1998. View

18.

McCune J . The dynamics of CD4+ T-cell depletion in HIV disease. Nature. 2001; 410(6831):974-9. DOI: 10.1038/35073648. View

19.

Muthukumar A, Zhou D, Paiardini M, Barry A, Cole K, McClure H . Timely triggering of homeostatic mechanisms involved in the regulation of T-cell levels in SIVsm-infected sooty mangabeys. Blood. 2005; 106(12):3839-45. PMC: 1895113. DOI: 10.1182/blood-2005-01-0394. View

20.

Johnson R, Kaur A . HIV: viral blitzkrieg. Nature. 2005; 434(7037):1080-1. DOI: 10.1038/4341080a. View