Synergistic Control of Cell Adhesion by Integrins and Syndecans

Overview

Journal Nat Rev Mol Cell Biol

Specialties Cell Biology
Molecular Biology

Date 2007 Nov 1

PMID 17971838

Citations 257

Authors

Mark R Morgan

Martin J Humphries

Mark D Bass

Affiliations

Soon will be listed here.

Abstract

The ability of cells to adhere to each other and to their surrounding extracellular matrices is essential for a multicellular existence. Adhesion provides physical support for cells, regulates cell positioning and enables microenvironmental sensing. The integrins and the syndecans are two adhesion receptor families that mediate adhesion, but their relative and functional contributions to cell-extracellular matrix interactions remain obscure. Recent advances have highlighted connections between the signalling networks that are controlled by these families of receptors. Here we survey the evidence that synergistic signalling is involved in controlling adhesive function and the regulation of cell behaviour in response to the external environment.

Citing Articles

Heparin Resistance in Patients Receiving Extracorporeal Membrane Oxygenation: A Review.

Li T, Zhailauova A, Kuanyshbek A, Wachruschew I, Tulegenov S, Sazonov V J Clin Med. 2025; 13(24.

PMID: 39768556 PMC: 11728406. DOI: 10.3390/jcm13247633.

Polysaccharide-based biomaterials for regenerative therapy in intervertebral disc degeneration.

Wang X, Huang Y, Yang Y, Tian X, Jin Y, Jiang W Mater Today Bio. 2025; 30:101395.

PMID: 39759846 PMC: 11699348. DOI: 10.1016/j.mtbio.2024.101395.

Endothelial eNOS deficiency causes podocyte injury through NFAT2 and heparanase in diabetic mice.

Katagiri D, Nagasaka S, Takahashi K, Wang S, Pozzi A, Zent R Sci Rep. 2024; 14(1):29179.

PMID: 39587144 PMC: 11589149. DOI: 10.1038/s41598-024-79501-0.

Integrin αVβ3 mediates porcine deltacoronavirus infection and inflammatory response through activation of the FAK-PI3K-AKT-nf-κB signalling pathway.

Jin X, Wu X, Li Z, Hu Y, Xia L, Zu S Virulence. 2024; 15(1):2407847.

PMID: 39368071 PMC: 11457627. DOI: 10.1080/21505594.2024.2407847.

Integrin β1 in breast cancer: mechanisms of progression and therapy.

Huang Q, Wang J, Ning H, Liu W, Han X Breast Cancer. 2024; 32(1):43-59.

PMID: 39343856 DOI: 10.1007/s12282-024-01635-w.

References

Wilcox-Adelman S, Denhez F, Goetinck P . Syndecan-4 modulates focal adhesion kinase phosphorylation. J Biol Chem. 2002; 277(36):32970-7. DOI: 10.1074/jbc.M201283200. View

Wang B, Xiao Y, Ding B, Zhang N, Yuan X, Gui L . Induction of tumor angiogenesis by Slit-Robo signaling and inhibition of cancer growth by blocking Robo activity. Cancer Cell. 2003; 4(1):19-29. DOI: 10.1016/s1535-6108(03)00164-8. View

Bass M, Roach K, Morgan M, Mostafavi-Pour Z, Schoen T, Muramatsu T . Syndecan-4-dependent Rac1 regulation determines directional migration in response to the extracellular matrix. J Cell Biol. 2007; 177(3):527-38. PMC: 1885470. DOI: 10.1083/jcb.200610076. View

Grootjans J, Zimmermann P, Reekmans G, Smets A, Degeest G, Durr J . Syntenin, a PDZ protein that binds syndecan cytoplasmic domains. Proc Natl Acad Sci U S A. 1998; 94(25):13683-8. PMC: 28366. DOI: 10.1073/pnas.94.25.13683. View

Marcoux N, Vuori K . EGF receptor mediates adhesion-dependent activation of the Rac GTPase: a role for phosphatidylinositol 3-kinase and Vav2. Oncogene. 2003; 22(38):6100-6. DOI: 10.1038/sj.onc.1206712. View

Koo B, Jung Y, Shin J, Han I, Mortier E, Zimmermann P . Structural basis of syndecan-4 phosphorylation as a molecular switch to regulate signaling. J Mol Biol. 2005; 355(4):651-63. DOI: 10.1016/j.jmb.2005.09.087. View

Zaidel-Bar R, Cohen M, Addadi L, Geiger B . Hierarchical assembly of cell-matrix adhesion complexes. Biochem Soc Trans. 2004; 32(Pt3):416-20. DOI: 10.1042/BST0320416. View

Stupack D, Puente X, Boutsaboualoy S, Storgard C, Cheresh D . Apoptosis of adherent cells by recruitment of caspase-8 to unligated integrins. J Cell Biol. 2001; 155(3):459-70. PMC: 2150834. DOI: 10.1083/jcb.200106070. View

Ezratty E, Partridge M, Gundersen G . Microtubule-induced focal adhesion disassembly is mediated by dynamin and focal adhesion kinase. Nat Cell Biol. 2005; 7(6):581-90. DOI: 10.1038/ncb1262. View

10.

Cukierman E, Pankov R, Stevens D, Yamada K . Taking cell-matrix adhesions to the third dimension. Science. 2001; 294(5547):1708-12. DOI: 10.1126/science.1064829. View

11.

Brooks P, Montgomery A, Rosenfeld M, Reisfeld R, Hu T, Klier G . Integrin alpha v beta 3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels. Cell. 1994; 79(7):1157-64. DOI: 10.1016/0092-8674(94)90007-8. View

12.

Mostafavi-Pour Z, Askari J, Parkinson S, Parker P, Ng T, Humphries M . Integrin-specific signaling pathways controlling focal adhesion formation and cell migration. J Cell Biol. 2003; 161(1):155-67. PMC: 2172880. DOI: 10.1083/jcb.200210176. View

13.

Hertle M, Kubler M, Leigh I, Watt F . Aberrant integrin expression during epidermal wound healing and in psoriatic epidermis. J Clin Invest. 1992; 89(6):1892-901. PMC: 295888. DOI: 10.1172/JCI115794. View

14.

Lee T, Poon R, Yuen A, Man K, Yang Z, Guan X . Rac activation is associated with hepatocellular carcinoma metastasis by up-regulation of vascular endothelial growth factor expression. Clin Cancer Res. 2006; 12(17):5082-9. DOI: 10.1158/1078-0432.CCR-05-2794. View

15.

Saoncella S, Echtermeyer F, Denhez F, Nowlen J, Mosher D, Robinson S . Syndecan-4 signals cooperatively with integrins in a Rho-dependent manner in the assembly of focal adhesions and actin stress fibers. Proc Natl Acad Sci U S A. 1999; 96(6):2805-10. PMC: 15850. DOI: 10.1073/pnas.96.6.2805. View

16.

Reynolds L, Conti F, Lucas M, Grose R, Robinson S, Stone M . Accelerated re-epithelialization in beta3-integrin-deficient- mice is associated with enhanced TGF-beta1 signaling. Nat Med. 2005; 11(2):167-74. DOI: 10.1038/nm1165. View

17.

Bernfield M, Gotte M, Park P, Reizes O, Fitzgerald M, Lincecum J . Functions of cell surface heparan sulfate proteoglycans. Annu Rev Biochem. 2000; 68:729-77. DOI: 10.1146/annurev.biochem.68.1.729. View

18.

Powell E, Mercado M, Geller H . Protein kinase C mediates neurite guidance at an astrocyte boundary. Glia. 2001; 33(4):288-97. DOI: 10.1002/1098-1136(20010315)33:4<288::aid-glia1027>3.0.co;2-r. View

19.

Hodivala-Dilke K, Reynolds A, Reynolds L . Integrins in angiogenesis: multitalented molecules in a balancing act. Cell Tissue Res. 2003; 314(1):131-44. DOI: 10.1007/s00441-003-0774-5. View

20.

Fears C, Woods A . The role of syndecans in disease and wound healing. Matrix Biol. 2006; 25(7):443-56. DOI: 10.1016/j.matbio.2006.07.003. View