Autogenous Immunity to Mouse Mammary Tumor Virus in Mouse Strains of High and Low Mammary Tumor Incidence

Overview

Journal Cancer Res

Specialty Oncology

Date 1976 Aug 1

PMID 179709

Citations 10

Authors

J N Ihle

L O Arthur

D L Fine

Affiliations

Soon will be listed here.

Abstract

Specific radioimmune precipitation assays were utilized to demonstrate the presence of precipitating antibodies to mouse mammary tumor virus (MMTV) in the high-spontaneous mammary tumor strains of mice: C3H/HeN+, GR/N, BALB/cfC3H, and C57BL/6 X C3H F1 (hereafter called B6C3F1). Antibody titers in C3H/HeN+ mice increased with age, with highest titers observed in tumor-bearing animals. MMTV-precipitating antibodies were not detectable by radioimmune precipitation assay in low-mammary tumor strains (AKR, BALB/c C57BL/6, and C3H/HeN-) but were detectable in MMTV-inoculated BALB/c mice. Appearance of antibodies preceded palpable tumor formation, and antibody titers were directly correlated to virus dose. Natural antibody to MMTV in C3H/HeN+ and B6C3F1 mice coexists with the murine leukemia virus natural antibody as determined by competition radioimmunoassays.

Citing Articles

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Ross S Immunol Res. 1998; 17(1-2):209-16.

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Stutman O Springer Semin Immunopathol. 1982; 4(4):333-72.

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Effect of the age-related immune depression induced by MTV on the in vivo growth of a mammary carcinoma.

Tagliabue A, Luini W, De Vito G, Boraschi D Br J Cancer. 1981; 44(3):460-3.

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Virus-specific cytotoxic activity to mammary tumor cells of sera from normal and tumor-bearing mice with inhibition at low dilutions.

Creemers P Infect Immun. 1981; 32(1):15-23.

PMID: 6260679 PMC: 350579. DOI: 10.1128/iai.32.1.15-23.1981.

Monoclonal antibodies identify individual determinants on mouse mammary tumor virus glycoprotein gp52 with group, class, or type specificity.

Massey R, Arthur L, Nowinski R, Schochetman G J Virol. 1980; 34(3):635-43.

PMID: 6155475 PMC: 288751. DOI: 10.1128/JVI.34.3.635-643.1980.