» Articles » PMID: 17960096

Biological Activities of Hydrazone Derivatives

Overview
Journal Molecules
Publisher MDPI
Specialty Biology
Date 2007 Oct 26
PMID 17960096
Citations 163
Authors
Affiliations
Soon will be listed here.
Abstract

There has been considerable interest in the development of novel compounds with anticonvulsant, antidepressant, analgesic, antiinflammatory, antiplatelet, antimalarial, antimicrobial, antimycobacterial, antitumoral, vasodilator, antiviral and antischistosomiasis activities. Hydrazones possessing an azometine -NHN=CH- proton constitute an important class of compounds for new drug development. Therefore, many researchers have synthesized these compounds as target structures and evaluated their biological activities. These observations have been guiding for the development of new hydrazones that possess varied biological activities.

Citing Articles

Hydrazones, hydrazones-based coinage metal complexes, and their biological applications.

Tafere D, Gebrezgiabher M, Elemo F, Sani T, Atisme T, Ashebr T RSC Adv. 2025; 15(8):6191-6207.

PMID: 40034805 PMC: 11873977. DOI: 10.1039/d4ra07794f.


Hydrazone fluorescent sensors for the monitoring of toxic metals involved in human health from 2014-2024.

Ciupa A RSC Adv. 2025; 15(5):3465-3473.

PMID: 39906630 PMC: 11791624. DOI: 10.1039/d4ra09068c.


New quinazolone-sulfonate conjugates with an acetohydrazide linker as potential antimicrobial agents: design, synthesis and molecular docking simulations.

Kassem A, Ragab S, Omar M, Altwaijry N, Abdelraof M, Temirak A RSC Adv. 2025; 15(2):1033-1048.

PMID: 39807202 PMC: 11726445. DOI: 10.1039/d4ra07563c.


Antitumor Activity and Multi-Target Mechanism of Phenolic Schiff Bases Bearing Methanesulfonamide Fragments: Cell Cycle Analysis and a Molecular Modeling Study.

Abdel-Aziz A, El-Azab A, Brogi S, Ayyad R, Al-Suwaidan I, Hefnawy M Int J Mol Sci. 2025; 25(24.

PMID: 39769383 PMC: 11728000. DOI: 10.3390/ijms252413621.


Evaluation of hydrazone and -acylhydrazone derivatives of vitamin B6 and pyridine-4-carbaldehyde as potential drugs against Alzheimer's disease.

Bartolic M, Matosevic A, Marakovic N, Busic V, Roca S, Vikic-Topic D J Enzyme Inhib Med Chem. 2024; 39(1):2431832.

PMID: 39654394 PMC: 11633425. DOI: 10.1080/14756366.2024.2431832.


References
1.
Savini L, Chiasserini L, Travagli V, Pellerano C, Novellino E, Cosentino S . New alpha-(N)-heterocyclichydrazones: evaluation of anticancer, anti-HIV and antimicrobial activity. Eur J Med Chem. 2004; 39(2):113-22. DOI: 10.1016/j.ejmech.2003.09.012. View

2.
Cocco M, Congiu C, Lilliu V, Onnis V . Synthesis and in vitro antitumoral activity of new hydrazinopyrimidine-5-carbonitrile derivatives. Bioorg Med Chem. 2005; 14(2):366-72. DOI: 10.1016/j.bmc.2005.08.012. View

3.
Sah P, PEOPLES S . Isonicotinyl hydrazones as antitubercular agents and derivatives for identification of aldehydes and ketones. J Am Pharm Assoc Am Pharm Assoc. 1954; 43(9):513-24. DOI: 10.1002/jps.3030430902. View

4.
Ulgen M, Durgun B, Rollas S, Gorrod J . The in vitro hepatic microsomal metabolism of benzoic acid benzylidenehydrazide. Drug Metabol Drug Interact. 2011; 13(4):285-94. DOI: 10.1515/DMDI.1997.13.4.285. View

5.
Kucukguzel S, Oruc E, Rollas S, Sahin F, Ozbek A . Synthesis, characterisation and biological activity of novel 4-thiazolidinones, 1,3,4-oxadiazoles and some related compounds. Eur J Med Chem. 2002; 37(3):197-206. DOI: 10.1016/s0223-5234(01)01326-5. View