Synthesis and Properties of Injectable Hydrogel for Tissue Filling

Overview

Journal Pharmaceutics

Publisher MDPI

Date 2024 Mar 28

PMID 38543325

Authors

Chunyu Xie

Ga Liu

Lingshuang Wang

Qiang Yang

Fuying Liao

Xiao Yang

Bo Xiao

Lian Duan

Affiliations

Soon will be listed here.

Abstract

Hydrogels with injectability have emerged as the focal point in tissue filling, owing to their unique properties, such as minimal adverse effects, faster recovery, good results, and negligible disruption to daily activities. These hydrogels could attain their injectability through chemical covalent crosslinking, physical crosslinking, or biological crosslinking. These reactions allow for the formation of reversible bonds or delayed gelatinization, ensuring a minimally invasive approach for tissue filling. Injectable hydrogels facilitate tissue augmentation and tissue regeneration by offering slow degradation, mechanical support, and the modulation of biological functions in host cells. This review summarizes the recent advancements in synthetic strategies for injectable hydrogels and introduces their application in tissue filling. Ultimately, we discuss the prospects and prevailing challenges in developing optimal injectable hydrogels for tissue augmentation, aiming to chart a course for future investigations.

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