Increased Expression of HLRH-1 in Human Gastric Cancer and Its Implication in Tumorigenesis

Overview

Journal Mol Cell Biochem

Publisher Springer

Specialty Biochemistry

Date 2007 Oct 24

PMID 17952562

Citations 26

Authors

Shui-Liang Wang

De-Zhu Zheng

Feng-Hua Lan

Xiao-Jun Deng

Jian Zeng

Cheng-Jin Li

Rong Wang

Zhong-yong Zhu

Affiliations

Soon will be listed here.

Abstract

Altered signaling pathways or deregulated transcription factors represent an important category of molecular events leading to aberrant gene regulation in gastric cancer, among which the role of WNT/beta-catenin pathway remains unclear. LRH-1 is a critical transcription factor in controlling cell proliferation via crosstalk with the beta-catenin signaling pathway. In order to gain a knowledge of the expression of hLRH-1v1 and hLRH-1 in gastric cancer, a Q-PCR analysis was carried out. Our results showed that in about 50 and 47.6% of 42 tested patients with gastric cancer, the mRNA expression of hLRH-1v1 and hLRH-1 was significantly upregulated, as compared with self-paired normal control, respectively. Besides, overexpression of hLRH-1 was shown to promote the proliferation of gastric adenocarcinoma cell SGC-7901 via induction of cyclin E1. Taken together, our present study demonstrated for the first time the increased expression of hLRH-1v1 and hLRH-1 in human gastric cancer, an alteration which may implicate in tumorigenesis.

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References

Ebert M, Fei G, Kahmann S, Muller O, Yu J, Sung J . Increased beta-catenin mRNA levels and mutational alterations of the APC and beta-catenin gene are present in intestinal-type gastric cancer. Carcinogenesis. 2002; 23(1):87-91. DOI: 10.1093/carcin/23.1.87. View

Candidus S, Bischoff P, Becker K, Hofler H . No evidence for mutations in the alpha- and beta-catenin genes in human gastric and breast carcinomas. Cancer Res. 1996; 56(1):49-52. View

Schoonjans K, Dubuquoy L, Mebis J, Fayard E, Wendling O, Haby C . Liver receptor homolog 1 contributes to intestinal tumor formation through effects on cell cycle and inflammation. Proc Natl Acad Sci U S A. 2005; 102(6):2058-62. PMC: 548586. DOI: 10.1073/pnas.0409756102. View

Luo Y, Liang C, Tall A . The orphan nuclear receptor LRH-1 potentiates the sterol-mediated induction of the human CETP gene by liver X receptor. J Biol Chem. 2001; 276(27):24767-73. DOI: 10.1074/jbc.M100912200. View

Morin P, Sparks A, Korinek V, Barker N, Clevers H, Vogelstein B . Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC. Science. 1997; 275(5307):1787-90. DOI: 10.1126/science.275.5307.1787. View

Tetsu O, McCormick F . Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. Nature. 1999; 398(6726):422-6. DOI: 10.1038/18884. View

Fayard E, Auwerx J, Schoonjans K . LRH-1: an orphan nuclear receptor involved in development, metabolism and steroidogenesis. Trends Cell Biol. 2004; 14(5):250-60. DOI: 10.1016/j.tcb.2004.03.008. View

He T, Sparks A, Rago C, Hermeking H, Zawel L, DA COSTA L . Identification of c-MYC as a target of the APC pathway. Science. 1998; 281(5382):1509-12. DOI: 10.1126/science.281.5382.1509. View

Goodwin B, Jones S, Price R, Watson M, McKee D, Moore L . A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis. Mol Cell. 2000; 6(3):517-26. DOI: 10.1016/s1097-2765(00)00051-4. View

10.

Lu T, Makishima M, REPA J, Schoonjans K, Kerr T, Auwerx J . Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors. Mol Cell. 2000; 6(3):507-15. DOI: 10.1016/s1097-2765(00)00050-2. View

11.

Koh T, Bulitta C, Fleming J, Dockray G, Varro A, Wang T . Gastrin is a target of the beta-catenin/TCF-4 growth-signaling pathway in a model of intestinal polyposis. J Clin Invest. 2000; 106(4):533-9. PMC: 380254. DOI: 10.1172/JCI9476. View

12.

Moon R, Kohn A, De Ferrari G, Kaykas A . WNT and beta-catenin signalling: diseases and therapies. Nat Rev Genet. 2004; 5(9):691-701. DOI: 10.1038/nrg1427. View

13.

Kolligs F, Bommer G, Goke B . Wnt/beta-catenin/tcf signaling: a critical pathway in gastrointestinal tumorigenesis. Digestion. 2002; 66(3):131-44. DOI: 10.1159/000066755. View

14.

Nitta M, Ku S, Brown C, Okamoto A, Shan B . CPF: an orphan nuclear receptor that regulates liver-specific expression of the human cholesterol 7alpha-hydroxylase gene. Proc Natl Acad Sci U S A. 1999; 96(12):6660-5. PMC: 21971. DOI: 10.1073/pnas.96.12.6660. View

15.

Botrugno O, Fayard E, Annicotte J, Haby C, Brennan T, Wendling O . Synergy between LRH-1 and beta-catenin induces G1 cyclin-mediated cell proliferation. Mol Cell. 2004; 15(4):499-509. DOI: 10.1016/j.molcel.2004.07.009. View

16.

Woo D, Kim H, Lee H, Kang Y, Yang H, Kim W . Altered expression and mutation of beta-catenin gene in gastric carcinomas and cell lines. Int J Cancer. 2001; 95(2):108-13. DOI: 10.1002/1097-0215(20010320)95:2<108::aid-ijc1019>3.0.co;2-#. View

17.

Lee J, Abraham S, Kim H, Nam J, Choi C, Lee M . Inverse relationship between APC gene mutation in gastric adenomas and development of adenocarcinoma. Am J Pathol. 2002; 161(2):611-8. PMC: 1850731. DOI: 10.1016/S0002-9440(10)64216-2. View

18.

Hanahan D, Weinberg R . The hallmarks of cancer. Cell. 2000; 100(1):57-70. DOI: 10.1016/s0092-8674(00)81683-9. View

19.

Stock M, Otto F . Gene deregulation in gastric cancer. Gene. 2005; 360(1):1-19. DOI: 10.1016/j.gene.2005.06.026. View

20.

Crawford H, Fingleton B, Goss K, Rubinfeld B, Polakis P, Matrisian L . The metalloproteinase matrilysin is a target of beta-catenin transactivation in intestinal tumors. Oncogene. 1999; 18(18):2883-91. DOI: 10.1038/sj.onc.1202627. View