Tolerogenic Dendritic Cells in Health and Disease: Friend and Foe!

Overview

Journal Eur J Dermatol

Publisher John Libbey Eurotext

Specialty Dermatology

Date 2007 Oct 24

PMID 17951127

Citations 20

Authors

Henric S Adler

Kerstin Steinbrink

Affiliations

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Abstract

Dendritic cells (DC) are professional antigen presenting cells and crucial mediators of immune defence and tolerance. Experimental evidence in vitro and in vivo has shown that tolerogenic DCs (tDCs) contribute to prevention of autoimmunity and allergic reactions but might also worsen the course of cancer and certain infectious diseases. The development of in vitro protocols for the generation of human tDCs has greatly improved the knowledge of basic principles for tolerance induction by tDCs and fosters approaches for the therapeutic manipulation of tDCs in conditions such as severe autoimmunity, allergy or transplantation.

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