Anti-malarial Effect of Gum Arabic

Overview

Journal Malar J

Publisher Biomed Central

Specialty Tropical Medicine

Date 2011 May 24

PMID 21599958

Citations 12

Authors

Adil Ballal

Diwakar Bobbala

Syed M Qadri

Michael Foller

Daniela Kempe

Omaima Nasir

Amal Saeed

Florian Lang

Affiliations

Soon will be listed here.

Abstract

Background: Gum Arabic (GA), a nonabsorbable nutrient from the exudate of Acacia senegal, exerts a powerful immunomodulatory effect on dendritic cells, antigen-presenting cells involved in the initiation of both innate and adaptive immunity. On the other hand GA degradation delivers short chain fatty acids, which in turn have been shown to foster the expression of foetal haemoglobin in erythrocytes. Increased levels of erythrocyte foetal haemoglobin are known to impede the intraerythrocytic growth of Plasmodium and thus confer some protection against malaria. The present study tested whether gum arabic may influence the clinical course of malaria.

Methods: Human erythrocytes were in vitro infected with Plasmodium falciparum in the absence and presence of butyrate and mice were in vivo infected with Plasmodium berghei ANKA by injecting parasitized murine erythrocytes (1 × 10⁶) intraperitoneally. Half of the mice received gum arabic (10% in drinking water starting 10 days before the day of infection).

Results: According to the in vitro experiments butyrate significantly blunted parasitaemia only at concentrations much higher (3 mM) than those encountered in vivo following GA ingestion (<1 μM). According to the in vivo experiments the administration of gum arabic slightly but significantly decreased the parasitaemia and significantly extended the life span of infected mice.

Discussion: GA moderately influences the parasitaemia and survival of Plasmodium-infected mice. The underlying mechanism remained, however, elusive.

Conclusions: Gum arabic favourably influences the course of murine malaria.

Citing Articles

Gum Arabic Increases Phagocytosis of by Blood Leukocytes of Young and Old Healthy Volunteers.

Freibrodt C, Baien S, von Kockritz-Blickwede M, de Buhr N, Nau R, Seele J Antibiotics (Basel). 2024; 13(6).

PMID: 38927149 PMC: 11201184. DOI: 10.3390/antibiotics13060482.

The effect of gum Arabic supplementation on cathelicidin expression in monocyte derived macrophages in mice.

Siednamohammeddeen N, Badi R, Mohammeddeen T, Enan K, AmalSaeed BMC Complement Med Ther. 2022; 22(1):149.

PMID: 35650596 PMC: 9158159. DOI: 10.1186/s12906-022-03627-9.

A Review on the Main Phytoconstituents, Traditional Uses, Inventions, and Patent Literature of Gum Arabic Emphasizing .

Ashour M, Fatima W, Imran M, Ghoneim M, Alshehri S, Shakeel F Molecules. 2022; 27(4).

PMID: 35208961 PMC: 8874428. DOI: 10.3390/molecules27041171.

Of membranes and malaria: phospholipid asymmetry in Plasmodium falciparum-infected red blood cells.

Fraser M, Matuschewski K, Maier A Cell Mol Life Sci. 2021; 78(10):4545-4561.

PMID: 33713154 PMC: 11071739. DOI: 10.1007/s00018-021-03799-6.

Effects of Prebiotics and Probiotics on Honey Bees () Infected with the Microsporidian Parasite .

Borges D, Guzman-Novoa E, Goodwin P Microorganisms. 2021; 9(3).

PMID: 33668904 PMC: 7996622. DOI: 10.3390/microorganisms9030481.

References

Koka S, Lang C, Niemoeller O, Boini K, Nicolay J, M Huber S . Influence of NO synthase inhibitor L-NAME on parasitemia and survival of Plasmodium berghei infected mice. Cell Physiol Biochem. 2008; 21(5-6):481-8. DOI: 10.1159/000129641. View

Schwarzer E, Turrini F, Ulliers D, Giribaldi G, Ginsburg H, Arese P . Impairment of macrophage functions after ingestion of Plasmodium falciparum-infected erythrocytes or isolated malarial pigment. J Exp Med. 1992; 176(4):1033-41. PMC: 2119406. DOI: 10.1084/jem.176.4.1033. View

Al-Majed A, Mostafa A, Al-Rikabi A, Al-Shabanah O . Protective effects of oral arabic gum administration on gentamicin-induced nephrotoxicity in rats. Pharmacol Res. 2002; 46(5):445-51. DOI: 10.1016/s1043661802001251. View

Tyurina Y, Tyurin V, Zhao Q, Djukic M, Quinn P, Pitt B . Oxidation of phosphatidylserine: a mechanism for plasma membrane phospholipid scrambling during apoptosis?. Biochem Biophys Res Commun. 2004; 324(3):1059-64. DOI: 10.1016/j.bbrc.2004.09.102. View

Duranton C, M Huber S, Lang F . Oxidation induces a Cl(-)-dependent cation conductance in human red blood cells. J Physiol. 2002; 539(Pt 3):847-55. PMC: 2290198. DOI: 10.1113/jphysiol.2001.013040. View

Brugnara C, De Franceschi L, Alper S . Inhibition of Ca(2+)-dependent K+ transport and cell dehydration in sickle erythrocytes by clotrimazole and other imidazole derivatives. J Clin Invest. 1993; 92(1):520-6. PMC: 293641. DOI: 10.1172/JCI116597. View

Anderson D . Evidence for the safety of gum arabic (Acacia senegal (L.) Willd.) as a food additive--a brief review. Food Addit Contam. 1986; 3(3):225-30. DOI: 10.1080/02652038609373584. View

Perrine S, Ginder G, Faller D, Dover G, Ikuta T, Witkowska H . A short-term trial of butyrate to stimulate fetal-globin-gene expression in the beta-globin disorders. N Engl J Med. 1993; 328(2):81-6. DOI: 10.1056/NEJM199301143280202. View

Bernhardt I, Weiss E, Robinson H, Wilkins R, Bennekou P . Differential effect of HOE642 on two separate monovalent cation transporters in the human red cell membrane. Cell Physiol Biochem. 2007; 20(5):601-6. DOI: 10.1159/000107543. View

10.

Younes H, Garleb K, Behr S, Remesy C, Demigne C . Fermentable fibers or oligosaccharides reduce urinary nitrogen excretion by increasing urea disposal in the rat cecum. J Nutr. 1995; 125(4):1010-6. DOI: 10.1093/jn/125.4.1010. View

11.

Steinman R, Nussenzweig M . Avoiding horror autotoxicus: the importance of dendritic cells in peripheral T cell tolerance. Proc Natl Acad Sci U S A. 2002; 99(1):351-8. PMC: 117564. DOI: 10.1073/pnas.231606698. View

12.

Weber R . Lacking deoxygenation-linked interaction between cytoplasmic domain of band 3 and HbF from fetal red blood cells. Acta Physiol (Oxf). 2007; 191(3):247-52. DOI: 10.1111/j.1748-1716.2007.01736.x. View

13.

Brand V, Sandu C, Duranton C, Tanneur V, Lang K, M Huber S . Dependence of Plasmodium falciparum in vitro growth on the cation permeability of the human host erythrocyte. Cell Physiol Biochem. 2003; 13(6):347-56. DOI: 10.1159/000075122. View

14.

Henson P, Bratton D, Fadok V . The phosphatidylserine receptor: a crucial molecular switch?. Nat Rev Mol Cell Biol. 2001; 2(8):627-33. DOI: 10.1038/35085094. View

15.

Mahmud H, Mauro D, Qadri S, Foller M, Lang F . Triggering of suicidal erythrocyte death by amphotericin B. Cell Physiol Biochem. 2009; 24(3-4):263-70. DOI: 10.1159/000233251. View

16.

Lang K, Myssina S, Brand V, Sandu C, Lang P, Berchtold S . Involvement of ceramide in hyperosmotic shock-induced death of erythrocytes. Cell Death Differ. 2003; 11(2):231-43. DOI: 10.1038/sj.cdd.4401311. View

17.

Daugas E, Cande C, Kroemer G . Erythrocytes: death of a mummy. Cell Death Differ. 2001; 8(12):1131-3. DOI: 10.1038/sj.cdd.4400953. View

18.

Fadok V, Bratton D, Rose D, Pearson A, Ezekewitz R, Henson P . A receptor for phosphatidylserine-specific clearance of apoptotic cells. Nature. 2000; 405(6782):85-90. DOI: 10.1038/35011084. View

19.

Koka S, Foller M, Lamprecht G, Boini K, Lang C, M Huber S . Iron deficiency influences the course of malaria in Plasmodium berghei infected mice. Biochem Biophys Res Commun. 2007; 357(3):608-14. DOI: 10.1016/j.bbrc.2007.03.175. View

20.

Mankidy R, Faller D, Mabaera R, Lowrey C, Boosalis M, White G . Short-chain fatty acids induce gamma-globin gene expression by displacement of a HDAC3-NCoR repressor complex. Blood. 2006; 108(9):3179-86. PMC: 1895523. DOI: 10.1182/blood-2005-12-010934. View