Twenty Years of PSA: From Prostate Antigen to Tumor Marker

Overview

Journal Rev Urol

Date 2007 Oct 16

PMID 17934568

Citations 30

Authors

Gabriela De Angelis

Harry G Rittenhouse

Stephen D Mikolajczyk

L Blair Shamel

Axel Semjonow

Affiliations

Soon will be listed here.

Abstract

The measurement of prostate-specific antigen in serum is credited with dramatic advances in the early detection of men with prostatic carcinoma. This report summarizes the history of biochemical research and the current understanding and application of prostate-specific antigen in prostate cancer diagnostics.

Citing Articles

Health Policy for Prostate Cancer Early Detection in the European Union and the Impact of Opportunistic Screening: PRAISE-U Consortium.

Beyer K, Leenen R, Venderbos L, Helleman J, Denijs F, Bramer W J Pers Med. 2024; 14(1).

PMID: 38248785 PMC: 10819943. DOI: 10.3390/jpm14010084.

Diagnostic efficacy of systemic immune-inflammation biomarkers in benign prostatic hyperplasia using receiver operating characteristic and artificial neural network.

Ahmed R, Hamdy O, Awad R Sci Rep. 2023; 13(1):14801.

PMID: 37684320 PMC: 10491602. DOI: 10.1038/s41598-023-41781-3.

Enhancing clinical potential of liquid biopsy through a multi-omic approach: A systematic review.

Di Sario G, Rossella V, Famulari E, Maurizio A, Lazarevic D, Giannese F Front Genet. 2023; 14:1152470.

PMID: 37077538 PMC: 10109350. DOI: 10.3389/fgene.2023.1152470.

Downregulation of PGM5 expression correlates with tumor progression and poor prognosis in human prostate cancer.

Sun J, Wang F, Zhou H, Zhao C, Li K, Fan C Discov Oncol. 2022; 13(1):63.

PMID: 35819729 PMC: 9276915. DOI: 10.1007/s12672-022-00525-x.

Serum proteome modulations upon treatment provides biological insight on response to treatment in relapsed mantle cell lymphoma.

Lokhande L, Kuci Emruli V, Eskelund C, Kolstad A, Hutchings M, Raty R Cancer Rep (Hoboken). 2021; 5(7):e1524.

PMID: 34319003 PMC: 9327662. DOI: 10.1002/cnr2.1524.

References

Okihara K, Cheli C, Partin A, Fritche H, Chan D, Sokoll L . Comparative analysis of complexed prostate specific antigen, free prostate specific antigen and their ratio in detecting prostate cancer. J Urol. 2002; 167(5):2017-23; discussion 2023-4. DOI: 10.1016/s0022-5347(05)65075-6. View

Christensson A, LAURELL C, Lilja H . Enzymatic activity of prostate-specific antigen and its reactions with extracellular serine proteinase inhibitors. Eur J Biochem. 1990; 194(3):755-63. DOI: 10.1111/j.1432-1033.1990.tb19466.x. View

Berger A, Volgger H, Rogatsch H, Strohmeyer D, Steiner H, Klocker H . Screening with low PSA cutoff values results in low rates of positive surgical margins in radical prostatectomy specimens. Prostate. 2002; 53(3):241-5. DOI: 10.1002/pros.10167. View

Mikolajczyk S, Millar L, Marker K, Grauer L, Goel A, Cass M . Ala217 is important for the catalytic function and autoactivation of prostate-specific human kallikrein 2. Eur J Biochem. 1997; 246(2):440-6. DOI: 10.1111/j.1432-1033.1997.00440.x. View

Graves H, Kamarei M, Stamey T . Identity of prostate specific antigen and the semen protein P30 purified by a rapid chromatography technique. J Urol. 1990; 144(6):1510-5. DOI: 10.1016/s0022-5347(17)39788-4. View

Peter J, Unverzagt C, Krogh T, Vorm O, Hoesel W . Identification of precursor forms of free prostate-specific antigen in serum of prostate cancer patients by immunosorption and mass spectrometry. Cancer Res. 2001; 61(3):957-62. View

Oesterling J, Jacobsen S, Chute C, Guess H, Girman C, Panser L . Serum prostate-specific antigen in a community-based population of healthy men. Establishment of age-specific reference ranges. JAMA. 1993; 270(7):860-4. View

Schedlich L, Bennetts B, Morris B . Primary structure of a human glandular kallikrein gene. DNA. 1987; 6(5):429-37. DOI: 10.1089/dna.1987.6.429. View

Fradet Y, Saad F, Aprikian A, Dessureault J, Elhilali M, Trudel C . uPM3, a new molecular urine test for the detection of prostate cancer. Urology. 2004; 64(2):311-5. DOI: 10.1016/j.urology.2004.03.052. View

10.

Bussemakers M, van Bokhoven A, Verhaegh G, Smit F, Karthaus H, Schalken J . DD3: a new prostate-specific gene, highly overexpressed in prostate cancer. Cancer Res. 1999; 59(23):5975-9. View

11.

Sokoll L, Chan D . Prostate-specific antigen. Its discovery and biochemical characteristics. Urol Clin North Am. 1997; 24(2):253-9. DOI: 10.1016/s0094-0143(05)70370-0. View

12.

Nurmikko P, Vaisanen V, Piironen T, Lindgren S, Lilja H, Pettersson K . Production and characterization of novel anti-prostate-specific antigen (PSA) monoclonal antibodies that do not detect internally cleaved Lys145-Lys146 inactive PSA. Clin Chem. 2000; 46(10):1610-8. View

13.

Laxman B, Tomlins S, Mehra R, Morris D, Wang L, Helgeson B . Noninvasive detection of TMPRSS2:ERG fusion transcripts in the urine of men with prostate cancer. Neoplasia. 2006; 8(10):885-8. PMC: 1715928. DOI: 10.1593/neo.06625. View

14.

Clements J . The glandular kallikrein family of enzymes: tissue-specific expression and hormonal regulation. Endocr Rev. 1989; 10(4):393-419. DOI: 10.1210/edrv-10-4-393. View

15.

Kumar A, Mikolajczyk S, Goel A, Millar L, Saedi M . Expression of pro form of prostate-specific antigen by mammalian cells and its conversion to mature, active form by human kallikrein 2. Cancer Res. 1997; 57(15):3111-4. View

16.

Catalona W, Partin A, Slawin K, Brawer M, Flanigan R, Patel A . Use of the percentage of free prostate-specific antigen to enhance differentiation of prostate cancer from benign prostatic disease: a prospective multicenter clinical trial. JAMA. 1998; 279(19):1542-7. DOI: 10.1001/jama.279.19.1542. View

17.

Mikolajczyk S, Millar L, Kumar A, Saedi M . Human glandular kallikrein, hK2, shows arginine-restricted specificity and forms complexes with plasma protease inhibitors. Prostate. 1998; 34(1):44-50. DOI: 10.1002/(sici)1097-0045(19980101)34:1<44::aid-pros6>3.0.co;2-k. View

18.

GUTMAN A, Gutman E . AN " ACID " PHOSPHATASE OCCURRING IN THE SERUM OF PATIENTS WITH METASTASIZING CARCINOMA OF THE PROSTATE GLAND. J Clin Invest. 1938; 17(4):473-8. PMC: 434803. DOI: 10.1172/JCI100974. View

19.

Lilja H . Structure and function of prostatic- and seminal vesicle-secreted proteins involved in the gelation and liquefaction of human semen. Scand J Clin Lab Invest Suppl. 1988; 191:13-20. View

20.

Mikolajczyk S, Rittenhouse H . Pro PSA: a more cancer specific form of prostate specific antigen for the early detection of prostate cancer. Keio J Med. 2003; 52(2):86-91. DOI: 10.2302/kjm.52.86. View