Symmetry and Stochastic Gene Regulation
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Lorentz-like noncompact Lie symmetry SO(2,1) is found in a spin-boson stochastic model for gene expression. The invariant of the algebra characterizes the switch decay to equilibrium. The azimuthal eigenvalue describes the affinity between the regulatory protein and the gene operator site. Raising and lowering operators are constructed and their actions increase or decrease the affinity parameter. The classification of the noise regime of the gene arises from the group theoretical numbers.
Physical implications of so(2, 1) symmetry in exact solutions for a self-repressing gene.
Ramos A, Reinitz J J Chem Phys. 2019; 151(4):041101.
PMID: 31370538 PMC: 6934145. DOI: 10.1063/1.5105361.
Lessons and perspectives for applications of stochastic models in biological and cancer research.
Sabino A, Vasconcelos M, Sittoni M, Lautenschlager W, Queiroga A, Morais M Clinics (Sao Paulo). 2018; 73(suppl 1):e536s.
PMID: 30281699 PMC: 6131223. DOI: 10.6061/clinics/2018/e536s.
Gene regulation and noise reduction by coupling of stochastic processes.
Ramos A, Hornos J, Reinitz J Phys Rev E Stat Nonlin Soft Matter Phys. 2015; 91(2):020701.
PMID: 25768447 PMC: 4476401. DOI: 10.1103/PhysRevE.91.020701.