In Vitro Susceptibility of Methicillin-resistant Staphylococcus Aureus and Methicillin-susceptible Staphylococcus Aureus to a New Antimicrobial, Copper Silicate

Overview

Journal Antimicrob Agents Chemother

Publisher American Society for Microbiology

Specialty Pharmacology

Date 2007 Oct 3

PMID 17908948

Citations 5

Authors

Kerry C Carson

Jessica G Bartlett

Trina-Jean Tan

Thomas V Riley

Affiliations

Soon will be listed here.

Abstract

The soluble copper silicate (CS) MIC of 100 strains of methicillin-resistant Staphylococcus aureus and 100 strains of methicillin-susceptible S. aureus (MSSA) was 175 mg Cu/liter. Bactericidal and postantibiotic effects (> or =1 h) were seen at 2x MIC and 4x MIC. The frequency of mutation was <10(-9), and serial passage could not extend growth beyond 1.6x MIC.

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