Non-oncogene Addiction and the Stress Phenotype of Cancer Cells

Overview

Journal Cell

Publisher Cell Press

Specialty Cell Biology

Date 2007 Sep 25

PMID 17889643

Citations 179

Authors

Nicole L Solimini

Ji Luo

Stephen J Elledge

Affiliations

Soon will be listed here.

Abstract

Heat-shock factor 1 (HSF1) is a transcription factor that is activated upon proteotoxic stress and coordinates induction of the heat-shock response. In this issue, Dai et al. (2007) show that HSF1 is a potent modifier of tumorigenesis and is required for tumor initiation and maintenance in a variety of cancer models. These findings add HSF1 to a growing list of non-oncogenes that could be exploited as cancer drug targets.

Citing Articles

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Wei L, Deng C, Zhang B, Wang G, Meng Y, Qin H Mol Cancer Res. 2023; 22(1):55-69.

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