N-myc-Mediated Translation Control Is a Therapeutic Vulnerability in Medulloblastoma

Overview

Journal Cancer Res

Specialty Oncology

Date 2022 Oct 20

PMID 36264168

Authors

Duygu Kuzuoglu-Ozturk

Ozlem Aksoy

Christin Schmidt

Robin Lea

Jon D Larson

Ryan R L Phelps

Nicole Nasholm

Megan Holt

Adrian Contreras

Miller Huang

Shannon Wong-Michalak

Hao Shao

Robert Wechsler-Reya

Joanna J Phillips

Jason E Gestwicki

Davide Ruggero

William A Weiss

Affiliations

Soon will be listed here.

Abstract

Significance: Translatome analysis in medulloblastoma shows that N-myc drives selective translation of transcripts that promote protein homeostasis and that represent new therapeutic vulnerabilities.

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