RiVax, a Recombinant Ricin Subunit Vaccine, Protects Mice Against Ricin Delivered by Gavage or Aerosol

Overview

Journal Vaccine

Specialty Allergy & Immunology

Date 2007 Sep 19

PMID 17875350

Citations 61

Authors

Joan E Smallshaw

James A Richardson

Ellen S Vitetta

Affiliations

Soon will be listed here.

Abstract

Ricin is a plant toxin that is a CDC level B biothreat. Our recombinant ricin A chain vaccine (RiVax), which contains mutations in both known toxic sites, has no residual toxicity at doses at least 800 times the immunogenic dose. RiVax without adjuvant given intramuscularly (i.m.) protected mice against intraperitoneally administered ricin. Furthermore the vaccine without alum was safe and immunogenic in human volunteers. Here we describe the development of gavage and aerosol ricin challenge models in mice and demonstrate that i.m. vaccination protects mice against ricin delivered by either route. Also RiVax protects against aerosol-induced lung damage as determined by histology and lung function tests.

Citing Articles

Toxicity and Efficacy Evaluation of Soluble Recombinant Ricin Vaccine.

Yun H, Joe H, Song D, Song Y, Hong S, Kim C Vaccines (Basel). 2024; 12(10).

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Long-Term Pulmonary Damage in Surviving Antitoxin-Treated Mice following a Lethal Ricin Intoxication.

Gal Y, Sapoznikov A, Lazar S, Shoseyov D, Aftalion M, Gutman H Toxins (Basel). 2024; 16(2).

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The Search for Antidotes Against Ricin.

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Comparative Aspects of Ricin Toxicity by Inhalation.

Stoll A, Shenton D, Green A, Holley J Toxins (Basel). 2023; 15(4).

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Serum antibody profiling identifies vaccine-induced correlates of protection against aerosolized ricin toxin in rhesus macaques.

Roy C, Ehrbar D, Van Slyke G, Doering J, Didier P, Doyle-Meyers L NPJ Vaccines. 2022; 7(1):164.

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