Ricin: Mechanism of Toxicity, Clinical Manifestations, and Vaccine Development. A Review

Overview

Journal J Toxicol Clin Toxicol

Specialty Toxicology

Date 2004 Jun 25

PMID 15214627

Citations 19

Authors

Leah G Doan

Affiliations

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Abstract

Ricin is one of the most potent plant toxins known, and the castor plant from which it is derived, Ricinus communis, is ubiquitous. The harvesting of castor beans exceeds one million tons annually, and ricin is easier to produce than either anthrax or botulinum. As a result, ricin is a convenient, potent, and available toxin for terrorist acts. This paper will review the mechanism of toxicity, major clinical manifestations, treatment, current methods of detection, and vaccine development.

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