Radioguided Sentinel Lymph Node Dissection in Patients with Localised Prostate Carcinoma: Influence of the Dose of Radiolabelled Colloid to Avoid Failure of the Procedure

Overview

Journal Eur J Nucl Med Mol Imaging

Specialties Biophysics
Nuclear Medicine
Radiology

Date 2007 Sep 11

PMID 17828535

Citations 12

Authors

Isabelle Brenot-Rossi

Dominique Rossi

Benjamin Esterni

Serge Brunelle

Guillaume Chuto

Cyrille Bastide

Affiliations

Soon will be listed here.

Abstract

Introduction: The purpose of this study was to determine the role of the injected dose of tracer in the non-detection of pelvic sentinel lymph nodes (SLN) in patients with prostate carcinoma.

Methods: Data were evaluated from 100 patients (age range 43-77, mean 63 years). The first 72 patients (group 1) received 2 x 0.3 ml of 30 MBq-nanocolloid-99 mTc and the remaining 28 patients (group 2) received 2 x 0.3 ml of 100 MBq. Surgery consisted of the detection and dissection of lymph nodes identified as sentinel nodes, followed by an extended lymphadenectomy.

Results: SLNs were located in the interiliac group in 54.2% of patients, in the obturator fossa in 30.7%, in the external iliac group in 10.9% and in the common iliac group in 4.2% of cases. Lymph node involvement was observed in 12% of patients. But there was a 30.6% (22/72) failure rate of the SLN procedure in group 1 and 7.1% (2/28) in group 2. An increased risk of unsuccessful SLN procedure was statistically associated with the low dose of MBq-nanocolloids (p < 0.017). Statistical correlation is also found after the exclusion of the first 30 patients from the study (learning phase of the team) (p < 0.034). None of the other parameters showed a statistical association (age, p < 0.9; Gleason score, p < 0.3; grade pT, p < 0.7). A higher grade or a greater extension of cancer inside the prostate are not responsible for the failure of the SLN procedure.

Conclusion: It seems necessary to inject at least 200 MBq inside the prostate to avoid a failed SLN procedure.

Citing Articles

Sentinel Lymph Node Biopsy in Prostate Cancer: An Overview of Diagnostic Performance, Oncological Outcomes, Safety, and Feasibility.

Rossin G, Zorzi F, de Pablos-Rodriguez P, Biasatti A, Marenco J, Ongaro L Diagnostics (Basel). 2023; 13(15).

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A hybrid radioactive and fluorescence approach is more than the sum of its parts; outcome of a phase II randomized sentinel node trial in prostate cancer patients.

Wit E, KleinJan G, Berrens A, van Vliet R, van Leeuwen P, Buckle T Eur J Nucl Med Mol Imaging. 2023; 50(9):2861-2871.

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PSMA-targeting agents for radio- and fluorescence-guided prostate cancer surgery.

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Sentinel lymph node mapping using SPECT/CT and gamma probe in endometrial cancer: an analysis of parameters affecting detection rate.

Sahbai S, Taran F, Staebler A, Wallwiener D, Fougere C, Brucker S Eur J Nucl Med Mol Imaging. 2017; 44(9):1511-1519.

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Beyond penile cancer, is there a role for sentinel node biopsy in urological malignancies?.

Brouwer O, van der Poel H, Bevers R, van Gennep E, Horenblas S Clin Transl Imaging. 2016; 4(5):395-410.

PMID: 27738628 PMC: 5037151. DOI: 10.1007/s40336-016-0189-4.

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