Assessment of Myocardial Perfusion by Dynamic O-15-labeled Water PET Imaging: Validation of a New Fast Factor Analysis

Overview

Journal J Nucl Cardiol

Specialty Cardiology & Vascular Diseases

Date 2007 Sep 11

PMID 17826323

Citations 8

Authors

Itaru Adachi

Oliver Gaemperli

Ines Valenta

Tiziano Schepis

Patrick T Siegrist

Valerie Treyer

Cyrill Burger

Koichi Morita

Philipp A Kaufmann

Affiliations

Soon will be listed here.

Abstract

Background: Factor analysis (FA) is an established method for separating myocardium from blood pool by use of oxygen 15-labeled water and positron emission tomography for analyzing myocardial blood flow (MBF). Conventional FA methods generating images from sinograms (sinoFA) are time-consuming, whereas FA can be performed on the reconstructed images (reconFA) in a fraction of time. We validated the MBF values obtained by reconFA versus sinoFA.

Methods And Results: In 23 volunteers (mean age, 26.6 +/- 3.4 years) MBF was calculated from sinoFA and reconFA and blindly reanalyzed 1 month later by the same observer. Intraobserver agreement and reconFA-versus-sinoFA agreement were assessed according to Bland and Altman (BA). Reproducibility proved excellent for global sinoFA (r = 0.968; P < .001; BA limits, -0.617 to 0.676 mL x min(-1) x g(-1)) and slightly superior for reconFA (r = 0.979; P < .001; BA limits, -0.538 to 0.558 mL x min(-1) x g(-1)), with wider limits of agreement for segmental MBF from sinoFA (r = 0.777; P < .001; BA limits, -1.676 to 1.656 mL x min(-1) x g(-1)) and reconFA (r = 0.844; P < .001; BA limits, -1.999 to 1.992 mL x min(-1) x g(-1)). In addition, sinoFA and reconFA showed excellent correlation (r = 0.975, P < .001) and agreement (BA limits, -0.528 to 0.648 mL x min(-1) x g(-1)) for global and segmental values (r = 0.955; P < .001; BA limits, -1.371 to 1.491 mL x min(-1) x g(-1)).

Conclusions: Use of reconFA allows rapid and reliable quantitative MBF assessment with O-15-labeled water.

Citing Articles

Simultaneous N-Ammonia and gadolinium first-pass myocardial perfusion with quantitative hybrid PET-MR imaging: a phantom and clinical feasibility study.

Nazir M, Gould S, Milidonis X, Reyes E, Ismail T, Neji R Eur J Hybrid Imaging. 2019; 3(1):15.

PMID: 31544170 PMC: 6718374. DOI: 10.1186/s41824-019-0062-6.

15-O-water myocardial flow reserve PET and CT angiography by full hybrid PET/CT as a potential alternative to invasive angiography.

Thomassen A, Braad P, Pedersen K, Petersen H, Johansen A, Diederichsen A Int J Cardiovasc Imaging. 2018; 34(12):2011-2022.

PMID: 30066164 DOI: 10.1007/s10554-018-1420-3.

Multimodality quantitative assessments of myocardial perfusion using dynamic contrast enhanced magnetic resonance and O-labelled water positron emission tomography imaging.

Papanastasiou G, Williams M, Dweck M, Mirsadraee S, Weir N, Fletcher A IEEE Trans Radiat Plasma Med Sci. 2018; 2(3):259-271.

PMID: 30003181 PMC: 6037289. DOI: 10.1109/TRPMS.2018.2796626.

SPECT and PET imaging of angiogenesis and arteriogenesis in pre-clinical models of myocardial ischemia and peripheral vascular disease.

Hendrikx G, Voo S, Bauwens M, Post M, Mottaghy F Eur J Nucl Med Mol Imaging. 2016; 43(13):2433-2447.

PMID: 27517840 PMC: 5095166. DOI: 10.1007/s00259-016-3480-8.

Advanced tracers in PET imaging of cardiovascular disease.

Li Y, Zhang W, Wu H, Liu G Biomed Res Int. 2014; 2014:504532.

PMID: 25389529 PMC: 4214169. DOI: 10.1155/2014/504532.

References

Morita K, Tsukamoto T, Naya M, Noriyasu K, Inubushi M, Shiga T . Smoking cessation normalizes coronary endothelial vasomotor response assessed with 15O-water and PET in healthy young smokers. J Nucl Med. 2006; 47(12):1914-20. View

Chareonthaitawee P, Kaufmann P, Rimoldi O, Camici P . Heterogeneity of resting and hyperemic myocardial blood flow in healthy humans. Cardiovasc Res. 2001; 50(1):151-61. DOI: 10.1016/s0008-6363(01)00202-4. View

Lee J, Lee D, Ahn J, Yeo J, Cheon G, Kim S . Generation of parametric image of regional myocardial blood flow using H(2)(15)O dynamic PET and a linear least-squares method. J Nucl Med. 2005; 46(10):1687-95. View

Bergmann S, Fox K, RAND A, McElvany K, Welch M, Markham J . Quantification of regional myocardial blood flow in vivo with H215O. Circulation. 1984; 70(4):724-33. DOI: 10.1161/01.cir.70.4.724. View

Hermansen F, Ashburner J, Spinks T, Kooner J, Camici P, Lammertsma A . Generation of myocardial factor images directly from the dynamic oxygen-15-water scan without use of an oxygen-15-carbon monoxide blood-pool scan. J Nucl Med. 1998; 39(10):1696-702. View

Wyss C, Koepfli P, Namdar M, Siegrist P, Luscher T, Camici P . Tetrahydrobiopterin restores impaired coronary microvascular dysfunction in hypercholesterolaemia. Eur J Nucl Med Mol Imaging. 2004; 32(1):84-91. DOI: 10.1007/s00259-004-1621-y. View

Cerqueira M, Weissman N, Dilsizian V, Jacobs A, Kaul S, Laskey W . Standardized myocardial segmentation and nomenclature for tomographic imaging of the heart. A statement for healthcare professionals from the Cardiac Imaging Committee of the Council on Clinical Cardiology of the American Heart Association. Circulation. 2002; 105(4):539-42. DOI: 10.1161/hc0402.102975. View

Chareonthaitawee P, Christenson S, Anderson J, Kemp B, Hodge D, Ritman E . Reproducibility of measurements of regional myocardial blood flow in a model of coronary artery disease: Comparison of H215O and 13NH3 PET techniques. J Nucl Med. 2006; 47(7):1193-201. View

Bland J, Altman D . Statistical methods for assessing agreement between two methods of clinical measurement. Lancet. 1986; 1(8476):307-10. View

10.

Kaufmann P, Gnecchi-Ruscone T, Yap J, Rimoldi O, Camici P . Assessment of the reproducibility of baseline and hyperemic myocardial blood flow measurements with 15O-labeled water and PET. J Nucl Med. 1999; 40(11):1848-56. View

11.

Watabe H, Jino H, Kawachi N, Teramoto N, Hayashi T, Ohta Y . Parametric imaging of myocardial blood flow with 15O-water and PET using the basis function method. J Nucl Med. 2005; 46(7):1219-24. View

12.

Jagathesan R, Kaufmann P, Rosen S, Rimoldi O, Turkeimer F, Foale R . Assessment of the long-term reproducibility of baseline and dobutamine-induced myocardial blood flow in patients with stable coronary artery disease. J Nucl Med. 2005; 46(2):212-9. View

13.

Kaufmann P, Camici P . Myocardial blood flow measurement by PET: technical aspects and clinical applications. J Nucl Med. 2005; 46(1):75-88. View

14.

Wyss C, Koepfli P, Fretz G, Seebauer M, Schirlo C, Kaufmann P . Influence of altitude exposure on coronary flow reserve. Circulation. 2003; 108(10):1202-7. DOI: 10.1161/01.CIR.0000087432.63671.2E. View

15.

KETY S . Measurement of local contribution within the brain by means of inert, diffusible tracers; examination of the theory, assumptions and possible sources of error. Acta Neurol Scand Suppl. 1965; 14:20-3. DOI: 10.1111/j.1600-0404.1965.tb01947.x. View

16.

Frouin F, Merlet P, Bouchareb Y, Frouin V, Dubois-Rande J, De Cesare A . Validation of myocardial perfusion reserve measurements using regularized factor images of H(2)(15)O dynamic PET scans. J Nucl Med. 2001; 42(12):1737-46. View

17.

Katoh C, Morita K, Shiga T, Kubo N, Nakada K, Tamaki N . Improvement of algorithm for quantification of regional myocardial blood flow using 15O-water with PET. J Nucl Med. 2004; 45(11):1908-16. View

18.

Araujo L, Lammertsma A, Rhodes C, McFalls E, Iida H, Rechavia E . Noninvasive quantification of regional myocardial blood flow in coronary artery disease with oxygen-15-labeled carbon dioxide inhalation and positron emission tomography. Circulation. 1991; 83(3):875-85. DOI: 10.1161/01.cir.83.3.875. View

19.

Knabb R, Fox K, Sobel B, Bergmann S . Characterization of the functional significance of subcritical coronary stenoses with H(2)15O and positron-emission tomography. Circulation. 1985; 71(6):1271-8. DOI: 10.1161/01.cir.71.6.1271. View

20.

Siegrist P, Gaemperli O, Koepfli P, Schepis T, Namdar M, Valenta I . Repeatability of cold pressor test-induced flow increase assessed with H(2)(15)O and PET. J Nucl Med. 2006; 47(9):1420-6. View