Structures of Proteins of Biomedical Interest from the Center for Eukaryotic Structural Genomics

Overview

Journal J Struct Funct Genomics

Specialty Genetics

Date 2007 Sep 6

PMID 17786587

Citations 7

Authors

George N Phillips Jr

Brian G Fox

John L Markley

Brian F Volkman

Euiyoung Bae

Eduard Bitto

Craig A Bingman

Ronnie O Frederick

Jason G McCoy

Betsy L Lytle

Brad S Pierce

Jikui Song

Simon N Twigger

Affiliations

Soon will be listed here.

Abstract

The Center for Eukaryotic Structural Genomics (CESG) produces and solves the structures of proteins from eukaryotes. We have developed and operate a pipeline to both solve structures and to test new methodologies. Both NMR and X-ray crystallography methods are used for structure solution. CESG chooses targets based on sequence dissimilarity to known structures, medical relevance, and nominations from members of the scientific community. Many times proteins qualify in more than one of these categories. Here we review some of the structures that have connections to human health and disease.

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