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For IRES Trans-acting Factors, It is All About Location

Overview
Journal Oncogene
Date 2007 Sep 4
PMID 17767196
Citations 56
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Abstract

The translation of many proteins involved in transcription, cell cycle progression, apoptosis and cell survival is mediated by internal ribosome entry sites (IRESs) present within the 5'-untranslated regions (5'-UTRs) of their messenger RNA molecules (mRNAs). Several recent reports now demonstrate that the proteins controlling IRES-dependent translation initiation are regulated by their subcellular localization.

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