Identification of Lynch Syndrome: How Should We Proceed in the 21st Century?

Overview

Journal World J Gastroenterol

Publisher Baishideng Publishing Group

Specialty Gastroenterology

Date 2007 Aug 29

PMID 17724794

Authors

Antoni Castells

Francesc Balaguer

Sergi Castellvi-Bel

Victoria Gonzalo

Teresa Ocana

Affiliations

Soon will be listed here.

Abstract

Lynch syndrome, also known as hereditary non-polyposis colorectal cancer (HNPCC), is the most common form of hereditary colorectal cancer. Although great advances in the understanding of its molecular basis have taken place in the last decade, optimal selection of individuals for HNPCC genetic testing remains controversial. This is especially relevant since colonoscopy has been proven effective for reducing colorectal cancer incidence and mortality in individuals at-risk for this disorder. In this manuscript, we summarize the most significant contributions to this important issue that have appeared in the last few years.

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