Reduced Expression of RASSF1A in Esophageal and Nasopharyngeal Carcinomas Significantly Correlates with Tumor Stage

Overview

Journal Cancer Lett

Specialty Oncology

Date 2007 Aug 28

PMID 17720308

Citations 11

Authors

Paulisally Hau Yi Lo

Dan Xie

King Chi Chan

Fang-Ping Xu

Igor Kuzmin

Michael I Lerman

Simon Law

Daniel Chua

Jonathan Sham

Maria Li Lung

Affiliations

Soon will be listed here.

Abstract

Reduced expression or loss of tumor suppressor genes play a key role in many cancers. In this study, we investigated the role of RASSF1A in the pathogenesis of esophageal squamous cell carcinoma (ESCC) and nasopharyngeal carcinoma (NPC). We detected the down-regulated expression of both RASSF1A transcripts and protein in tumor tissues using RT-PCR and tissue microarray immunohistochemical staining analyses. Down-regulated expression of RASSF1A showed a significant association with WHO grade, tumor status, and lymph node metastasis, showing its possible utility as a biomarker for clinical specimens.

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