NALP Inflammasomes: a Central Role in Innate Immunity

Overview

Journal Semin Immunopathol

Publisher Springer

Specialties Allergy & Immunology
Pathology

Date 2007 Aug 19

PMID 17703304

Citations 84

Authors

Fabio Martinon

Olivier Gaide

Virgine Petrilli

Annick Mayor

Jurg Tschopp

Affiliations

Soon will be listed here.

Abstract

Inflammasomes are cytoplasmic multiprotein complexes that mediate the maturation of the proinflammatory cytokines interleukin-1beta (IL-1beta), IL-18, and possibly IL-33 by controlling the activation of the inflammatory caspases-1 and -5. Assembly of inflammasomes depends on NOD-like receptor (NLR) family members such as NALPs, NAIP, and IPAF. Various microbial and endogenous stimuli activate different types of inflammasomes. This article focuses on the Pyrin domain containing NLRs, known as NALP proteins. Recent findings provide exciting insights into how these proteins might be activated and also provide evidence of the critical role of the NALP inflammasomes in innate immunity and inflammatory diseases.

Citing Articles

Replicating Dynamic Immune Responses at Single-Cell Resolution within a Microfluidic Human Skin Equivalent.

Hindle S, Bachas Brook H, Chrysanthou A, Chambers E, Caley M, Connelly J Adv Sci (Weinh). 2025; 12(10):e2415717.

PMID: 39836544 PMC: 11905070. DOI: 10.1002/advs.202415717.

Celastrol Regulates the Hsp90-NLRP3 Interaction to Alleviate Rheumatoid Arthritis.

Yang J, He B, Dang L, Liu J, Liu G, Zhao Y Inflammation. 2024; 48(1):346-360.

PMID: 38874810 DOI: 10.1007/s10753-024-02060-z.

The NLRP3 Inflammasome as a Pathogenic Player Showing Therapeutic Potential in Rheumatoid Arthritis and Its Comorbidities: A Narrative Review.

Chen P, Tang K, Chen D Int J Mol Sci. 2024; 25(1).

PMID: 38203796 PMC: 10779699. DOI: 10.3390/ijms25010626.

TLR4 sensing of IsdB of induces a proinflammatory cytokine response via the NLRP3-caspase-1 inflammasome cascade.

Izquierdo Gonzalez J, Hossain M, Neef J, Zwack E, Tsai C, Raafat D mBio. 2023; 15(1):e0022523.

PMID: 38112465 PMC: 10790753. DOI: 10.1128/mbio.00225-23.

Polyphenols, flavonoids and inflammasomes: the role of cigarette smoke in COPD.

Fu Y, Kang N, Yu Y, Mi Y, Guo J, Wu J Eur Respir Rev. 2022; 31(164).

PMID: 35705209 PMC: 9648508. DOI: 10.1183/16000617.0028-2022.

References

Jones J, Dangl J . The plant immune system. Nature. 2006; 444(7117):323-9. DOI: 10.1038/nature05286. View

Johnston J, Barrett J, Nazarian S, Goodwin M, Ricciuto D, Ricuttio D . A poxvirus-encoded pyrin domain protein interacts with ASC-1 to inhibit host inflammatory and apoptotic responses to infection. Immunity. 2005; 23(6):587-98. DOI: 10.1016/j.immuni.2005.10.003. View

Pelegrin P, Surprenant A . Pannexin-1 couples to maitotoxin- and nigericin-induced interleukin-1beta release through a dye uptake-independent pathway. J Biol Chem. 2006; 282(4):2386-94. DOI: 10.1074/jbc.M610351200. View

Tong Z, Gold L, Pfeifer K, Dorward H, Lee E, Bondy C . Mater, a maternal effect gene required for early embryonic development in mice. Nat Genet. 2000; 26(3):267-8. DOI: 10.1038/81547. View

Miller D, Ayala J, Egger L, Raju S, Yamin T, Ding G . Purification and characterization of active human interleukin-1 beta-converting enzyme from THP.1 monocytic cells. J Biol Chem. 1993; 268(24):18062-9. View

Burger D, Dayer J, Palmer G, Gabay C . Is IL-1 a good therapeutic target in the treatment of arthritis?. Best Pract Res Clin Rheumatol. 2006; 20(5):879-96. DOI: 10.1016/j.berh.2006.06.004. View

Aravind L, Dixit V, Koonin E . Apoptotic molecular machinery: vastly increased complexity in vertebrates revealed by genome comparisons. Science. 2001; 291(5507):1279-84. DOI: 10.1126/science.291.5507.1279. View

Nakao S, Kuwano T, Tsutsumi-Miyahara C, Ueda S, Kimura Y, Hamano S . Infiltration of COX-2-expressing macrophages is a prerequisite for IL-1 beta-induced neovascularization and tumor growth. J Clin Invest. 2005; 115(11):2979-91. PMC: 1257532. DOI: 10.1172/JCI23298. View

Hubert D, Tornero P, Belkhadir Y, Krishna P, Takahashi A, Shirasu K . Cytosolic HSP90 associates with and modulates the Arabidopsis RPM1 disease resistance protein. EMBO J. 2003; 22(21):5679-89. PMC: 275404. DOI: 10.1093/emboj/cdg547. View

10.

Gu Y, Kuida K, Tsutsui H, Ku G, Hsiao K, Fleming M . Activation of interferon-gamma inducing factor mediated by interleukin-1beta converting enzyme. Science. 1997; 275(5297):206-9. DOI: 10.1126/science.275.5297.206. View

11.

Amer A, Franchi L, Kanneganti T, Body-Malapel M, Ozoren N, Brady G . Regulation of Legionella phagosome maturation and infection through flagellin and host Ipaf. J Biol Chem. 2006; 281(46):35217-23. DOI: 10.1074/jbc.M604933200. View

12.

Peter M, Krammer P . The CD95(APO-1/Fas) DISC and beyond. Cell Death Differ. 2003; 10(1):26-35. DOI: 10.1038/sj.cdd.4401186. View

13.

Martinon F, Hofmann K, Tschopp J . The pyrin domain: a possible member of the death domain-fold family implicated in apoptosis and inflammation. Curr Biol. 2001; 11(4):R118-20. DOI: 10.1016/s0960-9822(01)00056-2. View

14.

Bos J, Kanneganti T, Young C, Cakir C, Huitema E, Win J . The C-terminal half of Phytophthora infestans RXLR effector AVR3a is sufficient to trigger R3a-mediated hypersensitivity and suppress INF1-induced cell death in Nicotiana benthamiana. Plant J. 2006; 48(2):165-76. DOI: 10.1111/j.1365-313X.2006.02866.x. View

15.

Thornberry N, Bull H, Calaycay J, Chapman K, Howard A, Kostura M . A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes. Nature. 1992; 356(6372):768-74. DOI: 10.1038/356768a0. View

16.

Aravind L, Dixit V, Koonin E . The domains of death: evolution of the apoptosis machinery. Trends Biochem Sci. 1999; 24(2):47-53. DOI: 10.1016/s0968-0004(98)01341-3. View

17.

Martinon F, Glimcher L . Gout: new insights into an old disease. J Clin Invest. 2006; 116(8):2073-5. PMC: 1523387. DOI: 10.1172/JCI29404. View

18.

Mestre P, Baulcombe D . Elicitor-mediated oligomerization of the tobacco N disease resistance protein. Plant Cell. 2006; 18(2):491-501. PMC: 1356554. DOI: 10.1105/tpc.105.037234. View

19.

Endrizzi M, Hadinoto V, Growney J, Miller W, Dietrich W . Genomic sequence analysis of the mouse Naip gene array. Genome Res. 2000; 10(8):1095-102. PMC: 310933. DOI: 10.1101/gr.10.8.1095. View

20.

van der Biezen E, Jones J . Plant disease-resistance proteins and the gene-for-gene concept. Trends Biochem Sci. 1998; 23(12):454-6. DOI: 10.1016/s0968-0004(98)01311-5. View