Cytotoxic Small Molecule Dimers and Their Inhibitory Activity Against Human Breast Cancer Cells

Overview

Journal Bioorg Med Chem Lett

Specialty Biochemistry

Date 2007 Jul 28

PMID 17656092

Citations 2

Authors

M Kyle Hadden

Brian S J Blagg

Affiliations

Soon will be listed here.

Abstract

Small molecules based upon natural product dimers that exhibit cytotoxic activity were synthesized and evaluated for their anti-proliferative activity in human breast cancer cell lines. A central isophthalic core structure linking aromatic amines containing 3,5-disubstitutions produced the most active compounds. This series of compounds was found to be more active against the estrogen receptor positive cell line MCF-7 than the estrogen receptor negative cell line, SKBr3.

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