Hippocampal Neurogenesis, Depressive Disorders, and Antidepressant Therapy

Overview

Journal Neural Plast

Specialty Neurology

Date 2007 Jul 21

PMID 17641737

Citations 34

Authors

Eleni Paizanis

Michel Hamon

Laurence Lanfumey

Affiliations

Soon will be listed here.

Abstract

There is a growing body of evidence that neural stem cells reside in the adult central nervous system where neurogenesis occurs throughout lifespan. Neurogenesis concerns mainly two areas in the brain: the subgranular zone of the dentate gyrus in the hippocampus and the subventricular zone, where it is controlled by several trophic factors and neuroactive molecules. Neurogenesis is involved in processes such as learning and memory and accumulating evidence implicates hippocampal neurogenesis in the physiopathology of depression. We herein review experimental and clinical data demonstrating that stress and antidepressant treatments affect neurogenesis in opposite direction in rodents. In particular, the stimulation of hippocampal neurogenesis by all types of antidepressant drugs supports the view that neuroplastic phenomena are involved in the physiopathology of depression and underlie--at least partly--antidepressant therapy.

Citing Articles

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Effects of Positive Fighting Experience and Its Subsequent Deprivation on the Expression Profile of Mouse Hippocampal Genes Associated with Neurogenesis.

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