Modulation of in Vitro Erythropoiesis. The Influence of Beta-adrenergic Agonists on Erythroid Colony Formation

Overview

Journal J Clin Invest

Specialty General Medicine

Date 1977 Jul 1

PMID 17618

Citations 11

Authors

J E Brown

J W Adamson

Affiliations

Soon will be listed here.

Abstract

Canine marrow erythroid colony growth is enhanced by agents linked to the adenyl cyclase/cyclic AMP (cAMP) system, including cAMP, a phosphodieterase inhibitor (RO-20-1724), cholera enterotoxin, and beta-adrenergic agonists. The adrenergic effect is mediated by receptors having beta2-subspecificity. These receptors are distinct from putative receptors for erythropoietin and those acted upon by cholera enterotoxin. In addition, the population of cells most responsive to beta-agonists is distinct from the majority of erythropoientin-responsive cells, perhaps representing a subpopulation of this class of cell. This demonstration of an adenyl cyclase-linked mechanism regulating mammalian erythroid colony growth provides a model for the modulation by other hormones or small molecules of in vitro and, perhaps, in vivo erythropoiesis.

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