Angiotensin-(1-7): Pharmacology and New Perspectives in Cardiovascular Treatments

Overview

Journal Cardiovasc Drug Rev

Specialties Cardiology & Vascular Diseases
Pharmacology

Date 2007 Jul 7

PMID 17614938

Citations 42

Authors

Aaron J Trask

Carlos M Ferrario

Affiliations

Soon will be listed here.

Abstract

Many advances have been made in the cardiovascular field in the last several decades. Among them is the progress completed to date on the heptapeptide member of the renin-angiotensin system (RAS), angiotensin-(1-7) [Ang-(1-7)]. The peptide's beneficial actions against pathophysiological processes, such as cardiac arrhythmia, heart failure, hypertension, renal disease, preeclampsia, and even cancer are continuously being uncovered. This review encompasses the pharmacology of Ang-(1-7) and expounds upon the peptide's potential as a therapeutic agent against pathological processes both within and outside the cardiovascular continuum.

Citing Articles

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Transgenic rat with ubiquitous expression of angiotensin-(1-7)-producing fusion protein: a new tool to study the role of protective arm of the renin-angiotensin system in the pathophysiology of cardio-renal diseases.

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Activation of angiotensin-converting enzyme 2 ameliorates metabolic syndrome-induced renal damage in rats by renal TLR4 and nuclear transcription factor κB downregulation.

El-Domiaty H, Sweed E, Kora M, Zaki N, Khodir S Front Med (Lausanne). 2022; 9:904756.

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