Palliative Gastrectomy and Chemotherapy for Stage IV Gastric Cancer

Overview

Journal J Cancer Res Clin Oncol

Specialty Oncology

Date 2007 Jul 6

PMID 17611776

Citations 32

Authors

Sheng-Zhang Lin

Hong-Fei Tong

Tao You

Yao-Jun Yu

Wei-Jun Wu

Cong Chen

Wei Zhang

Bing Ye

Chun-Ming Li

Zhi-Qiang Zhen

Jia-Rong Xu

Jun-Liang Zhou

Affiliations

Soon will be listed here.

Abstract

Purpose: To investigate the value of palliative gastrectomy and chemotherapy in a large series of patients with stage IV gastric cancer.

Methods: A total of 389 patients were identified in survival analysis. Among which, 183 cases received palliative gastrectomy (PG) and 206 cases received unresectable operation, 184 cases received palliative chemotherapy (PC) and 205 cases did not receive chemotherapy. The survival advantages of patients, based on treatments modality, were also analyzed in patients with liver metastasis, peritoneal dissemination and lymph node metastasis.

Results: The 1-year, 3-year, 5-year survival rate of those patients who were treated with PG + PC were 85.7% (96/112), 32.1% (36/112), and 8.9% (10/112), which were far better than those who were not. For those patients with liver metastasis, peritoneal dissemination, and/or N3 lymph node metastasis, survival advantages were also present if treated with this multimodality approach.

Conclusion: The survival time and palliative duration were significantly longer in patients after PG than after non-resection operations. Postoperative chemotherapy prolonged the survival time of patients after palliative surgery. PG combined with adjuvant chemotherapy may improve survival in patients with stage IV gastric cancer, even with liver metastasis, peritoneal dissemination, and lymph node metastasis.

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