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Regulation of Membrane Fusion in Synaptic Excitation-secretion Coupling: Speed and Accuracy Matter

Overview
Journal Neuron
Publisher Cell Press
Specialty Neurology
Date 2007 Jul 6
PMID 17610814
Citations 86
Authors
Affiliations
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Abstract

Unlike most other secretory processes, neurotransmitter release at chemical synapses is extremely fast, tightly regulated, spatially restricted, and dynamically adjustable at the same time. In this review, we focus on recent discoveries of molecular and cell biological processes that determine how fusion competence of vesicles is achieved and controlled in order to suit the specific requirements of synaptic transmitter release with respect to speed and spatial selectivity.

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