Neurotransmitter Release Site Replenishment and Presynaptic Plasticity

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2021 Jan 5

PMID 33396919

Citations 8

Authors

Sumiko Mochida

Affiliations

Soon will be listed here.

Abstract

An action potential (AP) triggers neurotransmitter release from synaptic vesicles (SVs) docking to a specialized release site of presynaptic plasma membrane, the active zone (AZ). The AP simultaneously controls the release site replenishment with SV for sustainable synaptic transmission in response to incoming neuronal signals. Although many studies have suggested that the replenishment time is relatively slow, recent studies exploring high speed resolution have revealed SV dynamics with milliseconds timescale after an AP. Accurate regulation is conferred by proteins sensing Ca entering through voltage-gated Ca channels opened by an AP. This review summarizes how millisecond Ca dynamics activate multiple protein cascades for control of the release site replenishment with release-ready SVs that underlie presynaptic short-term plasticity.

Citing Articles

Single-vesicle imaging reveals actin-dependent spatial restriction of vesicles at the active zone, essential for sustained transmission.

Miki T, Okamoto Y, Ueno-Umegai M, Toyofuku R, Hattori S, Sakaba T Proc Natl Acad Sci U S A. 2024; 121(43):e2402152121.

PMID: 39405348 PMC: 11513904. DOI: 10.1073/pnas.2402152121.

Insights into Calpain Activation and Rho-ROCK Signaling in Parkinson's Disease and Aging.

Gathings A, Zaman V, Banik N, Haque A Biomedicines. 2024; 12(5).

PMID: 38791036 PMC: 11117523. DOI: 10.3390/biomedicines12051074.

Gens PSD-95 and GSK-3β expression improved by hair follicular stem cells-conditioned medium enhances synaptic transmission and cognitive abilities in the rat model of vascular dementia.

Ghobadi M, Akbari S, Bayat M, Shid Moosavi S, Salehi M, Pandamooz S Brain Behav. 2024; 14(1):e3351.

PMID: 38376050 PMC: 10757903. DOI: 10.1002/brb3.3351.

Mechanisms of Synaptic Vesicle Exo- and Endocytosis.

Mochida S Biomedicines. 2022; 10(7).

PMID: 35884898 PMC: 9313035. DOI: 10.3390/biomedicines10071593.

The regulatory role of NAAG-mGluR3 signaling on cortical synaptic plasticity after hypoxic ischemia.

Li K, Lu M, Cui M, Wang X, Zheng Y Cell Commun Signal. 2022; 20(1):55.

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