Oxazolones As Potent Inhibitors of 11beta-hydroxysteroid Dehydrogenase Type 1

Overview

Journal Bioorg Med Chem Lett

Specialty Biochemistry

Date 2007 Jun 30

PMID 17600707

Citations 4

Authors

Lori Sutin

Soren Andersson

Lars Bergquist

Victor M Castro

Eva Danielsson

Stephen James

Martin Henriksson

Lars Johansson

Christina Kaiser

Katarina Flyren

Meredith Williams

Affiliations

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Abstract

2,5,5-Trisubstituted oxazolones were identified as potent inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1). The synthesis, structure-activity relationship and metabolic stability of these compounds are presented.

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