Cross-seeding and Cross-competition in Mouse Apolipoprotein A-II Amyloid Fibrils and Protein A Amyloid Fibrils

Overview

Journal Am J Pathol

Publisher Elsevier

Specialty Pathology

Date 2007 Jun 27

PMID 17591964

Citations 21

Authors

Jingmin Yan

Xiaoying Fu

Fengxia Ge

Beiru Zhang

Junjie Yao

Huanyu Zhang

Jinze Qian

Hiroshi Tomozawa

Hironobu Naiki

Jinko Sawashita

Masayuki Mori

Keiichi Higuchi

Affiliations

Soon will be listed here.

Abstract

Murine senile [apolipoprotein A-II amyloid (AApoAII)] and reactive [protein A amyloid (AA)] amyloidosis are reported to be transmissible diseases via a seeding mechanism similar to that observed in the prion-associated disorders, although de novo amyloidogenesis and the progression of AApoAII or AA amyloidosis remain unclear. We examined the effect of co-injection of AApoAII and AA fibrils and multiple inflammatory stimuli in R1.P1-Apoa2(c) mice with the amyloidogenic Apoa2(c) allele. Both AApoAII and AA amyloidosis could be induced in this system, but the two types of amyloid fibrils preferentially promote the formation of the same type of fibrils while inhibiting the formation of the other. Furthermore, we demonstrate that AA or AApoAII amyloidosis could be cross-seeded by predeposited AApoAII or AA fibrils and that the predeposited amyloid fibrils were degraded when the fibril formation was reduced or stopped. In addition, a large proportion of the two amyloid fibrils colocalized during the formation of new fibrils in the spleen and liver. Thus, we propose that AApoAII and AA can both cross-seed and cross-compete with regard to amyloid formation, depending on the stage of amyloidogenesis. These results will aid in the clarification of the mechanisms of pathogenesis and progression of amyloid disorders.

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