Endosomal Signaling of Plant Steroid Receptor Kinase BRI1

Overview

Journal Genes Dev

Specialty Molecular Biology

Date 2007 Jun 21

PMID 17578906

Citations 176

Authors

Niko Geldner

Derek L Hyman

Xuelu Wang

Karin Schumacher

Joanne Chory

Affiliations

Soon will be listed here.

Abstract

The LRR receptor serine/threonine kinases are a major eukaryotic receptor family, for which the central regulatory mechanism of endosomal trafficking remains largely unadressed. We show that the steroid receptor BRI1 localizes to both plasma membrane and early endosomal compartments, even when observed at low, endogenous expression levels, and that its localization and turnover are independent of ligand. However, increasing endosomal localization of BRI1 enhances activation of the pathway and genomic responses. Our data indicate distinct signaling and trafficking mechanisms within this receptor class and show that the use of endosomes as signaling compartments is an unexpectedly broad phenomenon in eukaryotes.

Citing Articles

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