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Synthesis of Benzothiazole Semicarbazones As Novel Anticonvulsants--the Role of Hydrophobic Domain

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Specialty Biochemistry
Date 2007 Jun 19
PMID 17572089
Citations 17
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Abstract

A series of 1,3-benzothiazol-2-yl semicarbazones (1-15) were prepared in satisfactory yield and evaluated for their anticonvulsant, neurotoxicity and other toxicity studies. All the synthesized compounds were in good agreement with elemental and spectral data. Majority of the compounds were active in MES screen. Selected compounds were checked for their lipophilic character.

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