Diet During Pregnancy and Risk of Preeclampsia or Gestational Hypertension

Overview

Journal Ann Epidemiol

Publisher Elsevier

Specialty Public Health

Date 2007 May 25

PMID 17521921

Citations 66

Authors

Emily Oken

Yi Ning

Sheryl L Rifas-Shiman

Janet W Rich-Edwards

Sjurdur F Olsen

Matthew W Gillman

Affiliations

Soon will be listed here.

Abstract

Purpose: We sought to examine associations of first-trimester intake of calcium, n-3 and n-6 fatty acids, trans fatty acids, magnesium, folate, and vitamins C, D, and E with preeclampsia (PE) and gestational hypertension (GH).

Methods: We studied associations of diet with PE or GH among 1718 women in the prospective cohort study Project Viva, using logistic regression and adjusting for maternal age, prepregnancy body mass index, first trimester systolic blood pressure, race/ethnicity, education, and parity. We assessed first-trimester diet using a validated semiquantitative food frequency questionnaire.

Results: A total of 59 (3%) women developed PE, and 119 developed (7%) GH. We found a somewhat-lower risk of PE associated with higher intake of the elongated n-3 fatty acids docosahexaenoic and eicosapentaenoic acids (odds ratio [OR] 0.84, 95% confidence interval [95% CI]: 0.69-1.03 per 100 mg/day), fish (OR 0.91, 95% CI 0.75-1.09 per serving/day), and the ratio of docosahexaenoic + eicosapentaenoic to arachadonic acid (OR 0.82, 95% CI 0.66-1.01). We did not observe a lower risk of GH or PE with a greater intake of calcium; vitamin C, D, or E; milk; magnesium; folate; or with lower intake of n-6 or trans fatty acids.

Conclusions: Our results support a potential benefit for elongated n-3 fatty acids in preventing preeclampsia.

Citing Articles

A Review of Dietary and Lifestyle Management of Pre-Eclampsia and Postpartum Eclampsia.

Nadeem M, Javed K, Abid H, Hussain A, Khalid N Prev Nutr Food Sci. 2025; 30(1):1-20.

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Assessing the role of dietary acid load in the development of hypertensive disorders during pregnancy: uncovering the association through prospective cohort analysis.

Safarpour F, Shafaatdoost M, Naeimi R, Moini A, Pirjani R, Basirat Z Nutr J. 2024; 23(1):122.

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First trimester prenatal metal mixtures, vitamins, and hypertensive disorders of pregnancy in the project viva cohort.

Hernandez-Castro I, Rifas-Shiman S, Lin P, Chavarro J, Gold D, Zhang M Environ Int. 2024; 190:108909.

PMID: 39079333 PMC: 11389723. DOI: 10.1016/j.envint.2024.108909.

Gestational Diabetes Mellitus: What Can Medical Nutrition Therapy Do?.

Wei X, Zou H, Zhang T, Huo Y, Yang J, Wang Z Nutrients. 2024; 16(8).

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Association between Fish Consumption during Pregnancy and Maternal and Neonatal Outcomes: A Statistical Study in Southern Italy.

Alibrandi A, Zirilli A, Le Donne M, Giannetto C, Lanfranchi M, De Pascale A J Clin Med. 2024; 13(7).

PMID: 38610896 PMC: 11012849. DOI: 10.3390/jcm13072131.

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