Randomised Double-blind Trial of Bromovinyldeoxyuridine (BVDU) and Trifluorothymidine (TFT) in Dendritic Corneal Ulceration

Overview

Journal Br J Ophthalmol

Specialty Ophthalmology

Date 1991 Nov 1

PMID 1751456

Citations 6

Authors

W J Power

M Hillery

K Brady

L M Collum

Affiliations

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Abstract

The results of a randomised double-blind clinical trial of 0.1% bromovinyldeoxyuridine (BVDU) and 1% trifluorothymidine (TFT) in 60 patients with corneal dendritic ulceration are presented. There was no significant difference between BVDU and TFT in terms of numbers of ulcers healed (p = 0.61), mean healing time (p = 0.065), and cumulative healing rate (p = 0.058). No serious side effects were observed, though transient stinging was recorded in five patients receiving TFT and in three patients receiving BVDU. One patient in the group treated with TFT developed a punctate epitheliopathy.

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