Randomised Double-blind Trial of Acyclovir and Idoxuridine in Dendritic Corneal Ulceration

Overview

Journal Br J Ophthalmol

Specialty Ophthalmology

Date 1980 Oct 1

PMID 7000171

Citations 31

Authors

L M Collum

I B HILLARY

Affiliations

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Abstract

The results of a randomised double-blind clinical trial of 3% acyclovir and 0.5% idoxuridine (IDU) ophthalmic ointments in 60 patients with corneal dendritic ulceration are presented. Ulcers in all 30 patients treated with acyclovir healed compared with 22 (76%) of 29 patients treated with IDU (P < 0.01). Patients treated with acyclovir healed more rapidly (average 4.4 days) than those who received IDU (average 9.2 days) (P < 0.01). No serious side effects were observed, though transient stinging was recorded in 8 patients receiving acyclovir and in 2 patients receiving IDU. Other side effects in the IDU treated group were watering in 2 patients and superficial punctate erosions in 6 patients.

Citing Articles

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Antiviral treatment and other therapeutic interventions for herpes simplex virus epithelial keratitis.

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["Herpetic keratitis". Various expressions require different therapeutic approaches].

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