Emission of Characteristic Fluorescence from the Ligand-cytosine Complex in U_A/ACU Bulged RNA Duplex

Overview

Journal Bioorg Med Chem

Specialties Biochemistry
Chemistry

Date 2007 May 22

PMID 17513115

Citations 2

Authors

Jinhua Zhang

Fumie Takei

Kazuhiko Nakatani

Affiliations

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Abstract

Here we show that N,N-bis(3-aminopropyl)-2,7-diamino-1,8-naphthyridine (DANP) binds to the single cytosine bulge in RNA duplexes. When the base pairs flanking the C-bulge were A-U base pairs, a characteristic fluorescence was emitted from the DANP-C-bulge complex. The fluorescence would be useful for detecting the C-bulge in RNA secondary structures.

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