Immunology and Neurology

Overview

Journal J Neurol

Specialty Neurology

Date 2007 May 16

PMID 17503123

Citations 6

Authors

Eilhard Mix

Robert Goertsches

Uwe K Zettl

Affiliations

Soon will be listed here.

Abstract

The classical field of neuroimmunology deals with the immune response in infectious, autoimmune-mediated, ischemic, degenerative, traumatic, and neoplastic diseases of the nervous system with a major focus on immune-mediated demyelination. Recently more and more evidence points to a broader interaction between the immune and nervous systems via morphological connections, shared signal molecules and common mechanisms of signal transduction. Consequently, immune processes affect nervous functions and vice versa under both physiologic and pathologic conditions. This includes neuroendocrine (hormonal) and vegetative (neurotransmitter-mediated) influences on the immune response including conditioned immunostimulation and immunosuppression (neuroimmunomodulation) as well as effects of immune mediators (cytokines) on neuronal and psychic functions (psychoneuroimmunology). These findings have a strong impact on future strategies for the treatment of somatic as well as psychiatric diseases.

Citing Articles

A New Hypothesis on Anxiety, Sleep Insufficiency, and Viral Infections; Reciprocal Links to Consider in Today's "World vs. COVID-19" Endeavors.

Nami M, Mehrabi S, Kamali A, Kazemiha M, Carvalho J, Derman S Front Psychiatry. 2020; 11:585893.

PMID: 33250794 PMC: 7674554. DOI: 10.3389/fpsyt.2020.585893.

The effects of dopamine receptor 2 expression on B cells on bone metabolism and TNF-α levels in rheumatoid arthritis.

Wei L, Sun Y, Kong X, Zhang C, Yue T, Zhu Q BMC Musculoskelet Disord. 2016; 17:352.

PMID: 27542839 PMC: 4992283. DOI: 10.1186/s12891-016-1220-7.

Neuron-derived IgG protects neurons from complement-dependent cytotoxicity.

Zhang J, Niu N, Li B, McNutt M J Histochem Cytochem. 2013; 61(12):869-79.

PMID: 23979841 PMC: 3840743. DOI: 10.1369/0022155413504196.

Stress and allergic diseases.

Dave N, Xiang L, Rehm K, Marshall Jr G Immunol Allergy Clin North Am. 2010; 31(1):55-68.

PMID: 21094923 PMC: 3264048. DOI: 10.1016/j.iac.2010.09.009.

Animal models of multiple sclerosis--potentials and limitations.

Mix E, Meyer-Rienecker H, Hartung H, Zettl U Prog Neurobiol. 2010; 92(3):386-404.

PMID: 20558237 PMC: 7117060. DOI: 10.1016/j.pneurobio.2010.06.005.

References

Beeton C, Wulff H, Standifer N, Azam P, Mullen K, Pennington M . Kv1.3 channels are a therapeutic target for T cell-mediated autoimmune diseases. Proc Natl Acad Sci U S A. 2006; 103(46):17414-9. PMC: 1859943. DOI: 10.1073/pnas.0605136103. View

Cohen I, Young D . Autoimmunity, microbial immunity and the immunological homunculus. Immunol Today. 1991; 12(4):105-10. DOI: 10.1016/0167-5699(91)90093-9. View

Chandy K, DeCoursey T, Cahalan M, Gupta S . Electroimmunology: the physiologic role of ion channels in the immune system. J Immunol. 1985; 135(2 Suppl):787s-791s. View

Oviedo-Orta E, Evans W . Gap junctions and connexin-mediated communication in the immune system. Biochim Biophys Acta. 2004; 1662(1-2):102-12. DOI: 10.1016/j.bbamem.2003.10.021. View

Matsue H, Yao J, Matsue K, Nagasaka A, Sugiyama H, Aoki R . Gap junction-mediated intercellular communication between dendritic cells (DCs) is required for effective activation of DCs. J Immunol. 2005; 176(1):181-90. DOI: 10.4049/jimmunol.176.1.181. View

Hickey W, Hsu B, Kimura H . T-lymphocyte entry into the central nervous system. J Neurosci Res. 1991; 28(2):254-60. DOI: 10.1002/jnr.490280213. View

Meisel C, Schwab J, Prass K, Meisel A, Dirnagl U . Central nervous system injury-induced immune deficiency syndrome. Nat Rev Neurosci. 2005; 6(10):775-86. DOI: 10.1038/nrn1765. View

Pavlov V, Tracey K . Neural regulators of innate immune responses and inflammation. Cell Mol Life Sci. 2004; 61(18):2322-31. PMC: 11138906. DOI: 10.1007/s00018-004-4102-3. View

Wang H, Yu M, Ochani M, Amella C, Tanovic M, Susarla S . Nicotinic acetylcholine receptor alpha7 subunit is an essential regulator of inflammation. Nature. 2003; 421(6921):384-8. DOI: 10.1038/nature01339. View

10.

Strauss U, Schubert R, Jung S, Mix E . K+ currents of encephalitogenic memory T cells decrease with encephalitogenicity while interleukin-2 (IL-2) receptor expression remains stable during IL-2 dependent cell expansion. Recept Channels. 1998; 6(1):73-87. View

11.

Blass S, Engel J, Burmester G . [The immunologic homunculus in rheumatoid arthritis. A new viewpoint of immunopathogenesis in rheumatoid arthritis and therapeutic consequences]. Z Rheumatol. 2001; 60(1):1-16. DOI: 10.1007/s003930170093. View

12.

Strauss U, Herbrik M, Mix E, Bajorat R, Jung S, Gimsa U . Dopamine exerts no acute effects on Kv1.3 in activated encephalitogenic T cells. Neuroimmunomodulation. 2005; 12(1):45-53. DOI: 10.1159/000082363. View

13.

Felten D, Felten S, Bellinger D, Madden K . Fundamental aspects of neural-immune signaling. Psychother Psychosom. 1993; 60(1):46-56. DOI: 10.1159/000288679. View

14.

Khan A, Bose C, Yam L, Soloski M, Rupp F . Physiological regulation of the immunological synapse by agrin. Science. 2001; 292(5522):1681-6. DOI: 10.1126/science.1056594. View

15.

Strauss U, Wissel K, Jung S, Wulff H, Hansel W, Zhu J . K(+) channel-blocking alkoxypsoralens inhibit the immune response of encephalitogenic T line cells and lymphocytes from Lewis rats challenged for experimental autoimmune encephalomyelitis. Immunopharmacology. 2000; 48(1):51-63. DOI: 10.1016/s0162-3109(00)00177-6. View

16.

Merrill J, Benveniste E . Cytokines in inflammatory brain lesions: helpful and harmful. Trends Neurosci. 1996; 19(8):331-8. DOI: 10.1016/0166-2236(96)10047-3. View

17.

Schwartz M, Kipnis J . Protective autoimmunity and neuroprotection in inflammatory and noninflammatory neurodegenerative diseases. J Neurol Sci. 2005; 233(1-2):163-6. DOI: 10.1016/j.jns.2005.03.014. View

18.

Bechmann I . Failed central nervous system regeneration: a downside of immune privilege?. Neuromolecular Med. 2005; 7(3):217-28. DOI: 10.1385/NMM:7:3:217. View

19.

Besedovsky H, Del Rey A . The cytokine-HPA axis feed-back circuit. Z Rheumatol. 2001; 59 Suppl 2:II/26-30. DOI: 10.1007/s003930070014. View

20.

Stoll G, Jander S, Schroeter M . Detrimental and beneficial effects of injury-induced inflammation and cytokine expression in the nervous system. Adv Exp Med Biol. 2003; 513:87-113. DOI: 10.1007/978-1-4615-0123-7_3. View