Human Leukocyte Antigens HLA DRB1 Influence Clinical Outcome of Chronic Lymphocytic Leukemia?

Overview

Journal Haematologica

Specialty Hematology

Date 2007 May 10

PMID 17488703

Citations 3

Authors

Ewa Lech-Maranda

Przemyslaw Juszczynski

Anna Szmigielska-Kaplon

Krzysztof Jamroziak

Ewa Balcerczak

Tadeusz Robak

Affiliations

Soon will be listed here.

Abstract

We investigated HLA DRB1 correlations with chronic lymphocytic leukemia (B-CLL) outcome in 90 patients. Neither of the alleles was associated with B-CLL clinical characteristics or mortality. HLA DRB1*01 and HLA DRB1*02-null were associated with shorter overall survival (p=0.007, p=0.002). Our results suggest that HLA-restricted adaptive immunity influences CLL outcome.

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